Seizures/epilepsy Flashcards

1
Q

Define epilepsy

A

Tendency to recurring seizures

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2
Q

Differentials of a blackout/loss of consciousness (5)

A
Epileptic seizure
Syncope
Non-epileptic seizure, e.g. psychogenic seizure
Arrhythmia
Head trauma/concussive seizure
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3
Q

Name 3 types of syncope

A

Reflex syncope, e.g. after taking blood, straining on toilet
Orthostatic syncope, e.g. dehydration, anti-hypertensives
Cardiogenic syncope, e.g. arrhythmias

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4
Q

Questions to ask when assessing a collapse/blackout

  • patient account (3)
  • witness account (6)
A

Patient account

  • history of events leading up to collapse
  • history of the episode itself (any warning symptoms, awareness of it happening)
  • any recollection of what happened afterwards
Witness account
-how was the patient prior
-describe the patient during the episode:
eyes open/closed
any jerking
pallor
breathing pattern
duration
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5
Q

Seizure markers/signs (4)

A

Prolonged disorientation/confusion
Tongue biting
Incontinence
Muscle pains

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6
Q

Symptoms (4) /signs (2) of cardiogenic syncope, e.g. from arrhythmia

A

Chest pain
Dyspnoea
Clammy/sweaty
Palpitations

Pallor - pale grey
Few brief jerks

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7
Q

Symptoms (2) /signs (3) of reflex syncope, e.g. after blood taken

A

Lightheaded
Sweaty

Vision blacking out
Pale
Few brief jerks

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8
Q

Define a seizure

A

Sudden burst of electrical activity in brain temporarily affecting function

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9
Q

Causes of provoked seizures (4)

A

Alcohol/drug withdrawal
Within few days after head injury
Within 24hrs of stroke
Severe electrolyte disturbance

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10
Q

2 classifications of seizures

A

Generalised

Focal

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11
Q

Define generalised seizures vs focal seizures

A

Involve both hemispheres and therefore involve the whole body

Involves just one hemisphere

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12
Q

Name 6 types of generalised seizures

A
Absence seizures
Tonic seizures
Atonic seizures
Clonic seizures
Myoclonic seizures
Tonic-clonic seizures
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13
Q

Clinical features of absence seizures (2) + who are they found in most

A

Staring blankly for 5-10 secs
Automatisms - lip smacking, blinking

Children

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14
Q

Phases of a generalised tonic clonic seizure, formerly GRAND MAL seizure (2)

A

Tonic phase

  • body stiffens; goes rigid
  • cry or groan before clonic phase

Clonic phase

  • muscles rapidly rhythmically contract then relax
  • urinary incontinence
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15
Q

Clinical features of generalised tonic clonic seizures

  • tonic phase (4)
  • clonic phase (4)
  • post tonic-clonic state (1)
A
Tonic phase:
Loss of consciousness (not always) - collapse
Groaning
Stiff/rigid muscles initially
Tongue biting
Clonic phase:
Limb jerking - quick and rhythmic
Eyes open - staring or rolled upwards
Dribbling
Urinary incontinence

POST-ICTAL STATE (confusion for hours etc) after tonic clonic seizure stops

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16
Q

What are myoclonic seizures

  • characteristic feature
  • duration
A

Brief, shock like jerks/twitch of a muscle or a group of muscles, usually lasting no more than a second or two

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17
Q

What are atonic seizures

A

Sudden loss or decrease of normal muscle tone and the person often falls to the ground

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18
Q

What are tonic seizures

A

stiffening of your muscles. These seizures usually affect muscles in your back, arms and legs and may cause you to fall to the ground

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19
Q

What are clonic seizures

A

Repeated or rhythmic, jerking muscle movements

20
Q

Juvenile myoclonic epilepsy is a type of what generalised seizure + what is triggered by (2)

A

Myoclonic

Alcohol
Sleep deprivation - BIG RF

21
Q

List the 2 types of focal (partial seizures)

A

Focal aware seizure (used to be called simple partial seizure) = fully aware of what’s happening

Focal impaired awareness seizure (used to be called complex partial seizure) = change or loss of consciousness

22
Q

Are focal or generalised seizures more common in people with epilepsy

23
Q

Focal seizures most commonly arise from pathology in what lobe

24
Q

Symptoms/signs of focal seizures

  • motor (5)
  • sensory (4)

*mostly seen in focal AWARE seizures rather than focal impaired seizure

A

Motor:
Muscle jerking of one side of body/specific part of body
Automatisms - lip smacking, chewing, picking at clothes
Staring into space
Post-ictal weakness of one side

Sensory:
Feeling fear/anxiety
Feeling de ja vu
Aphasia
Changes to vision, hearing, smell, taste
25
List some automatisms (4)
Lip smacking Picking at clothes Chewing Eyelid fluttering
26
What are secondary generalised seizures
Focal seizures that have evolved into generalised seizures, i.e. once limited to one hemisphere but now affects brain bilaterally
27
Investigation of seizures (6)
``` EEG ECG - to rule out long QT syndrome FBC Blood glucose U+Es - maybe hypo/hypernatraemia, uraemia Toxicology screen - for illicit drugs CT ```
28
First line treatment drug options of ongoing *primary generalised epilepsies (4) + what class of drugs are they *e.g. tonic/atonic/clonic/tonic-clonic/myoclonic/absence seizures
Anticonvulsants: - sodium valproate - contraindicated in women of child bearing age OR - lamotrigine OR - topiramate OR - levetiracetam
29
First line treatment drug options of *focal seizures (4) + what drug class they are *e.g. focal aware or focal impaired seizure
Anticonvulsants: - Carbamazepine OR - Lamotrigine OR - Oxcarbazepine OR - Levetiracetam
30
First line treatment of absence seizures (1)
Ethosuximide
31
Treatment of an ACUTE generalised or focal seizure (2) - 1st line - 2nd line - if above doesn't work
IV benzodiazepine - lorazepam IV phenytoin (an anti-epileptic) - if above doesn't work
32
Side effects of the following anti-epileptics: - phenytoin (3) - sodium valproate (5) - carbamazepine (4) - lamotrigine (2) - levetiracetam (2)
Phenytoin - arrhythmia, hepatitis, drug-drug interactions Sodium valproate - tremor, ataxia, nausea, drowsy, hepatitis Carbamazepine - ataxia, drowsy, nystagmus, blurry vision Lamotrigine (best tolerated, least side effects) - skin rash, sleep disturbance Levetiracetam - irritable, depression
33
What is the best tolerated + least side effects anti-epileptic
Lamotrigine
34
What is status epilepticus + it is usually persistence/recurrence of which type of seizure
>5 mins of either continuous seizure activity OR repetitive seizures without regaining consciousness between them for >5 mins Tonic-clonic seizure
35
Treatment of status epilepticus | -1st line (2)
First line - 100% oxygen - IV benzodiazepine - lorazepam
36
Risk factors of status epileptics (2)
Not taking anticonvulsants properly | Chronic alcohol
37
Why is it important to treat an acute or prolonged seizure ASAP
During long convulsive seizures, body struggles to circulate oxygen so brain doesn't get enough oxygen and can lead to brain damage so important to give oxygen ASAP
38
After a SINGLE SEIZURE, someone can drive a car/HGV after how long if investigations are normal and no further seizures
Car - 6 months HGV - 5 years
39
Patients DIAGNOSED WITH EPILEPSY can drive a car once they have been seizure free or have only had seizures arising from sleep after how long
1 year
40
If patients with epilepsy have daytime seizures but then becomes nocturnal, how long does this have to be established before they can drive a car
3 years
41
Epileptics can only drive a HGV/PSC if they have been seizure free for how long + if they're not on anti-epileptics
10 years
42
What is the post-ictal state
Altered state of consciousness after an epileptic seizure | -confusion, drowsy, amnesia for hours after seizure
43
Absence seizure can be reliably tested by doing what
Inducing it by HYPERVENTILATION
44
Focal seizures are often preceded by what weird sign
Smelling a weird burnt smell or hallucinating
45
Focal seizures often secondary generalise into what type of seizure
Tonic clonic