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Top 300 > Seizures > Flashcards

Seizures Flashcards

1
Q

Which seizure meds are pregnancy category D ?

A

Cbz, clonazepam, phenobarbital
Phenytoin
Topamax
Valproate

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2
Q

Which 3 seizure meds are associated with weight loss?

A

Topiramate
Levetiracetam
Zonisamide

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3
Q

______fast sodium channel blocker; structually similar to tricyclic antidepressants; stimulates release of ADH promoting reabsorprion of water

A

Cbz

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4
Q

_____T-type calcium channel blocker that increases seizure threshold and suppresses paroxysmal spike and wave pattern in absence seizures

A

Ethosuximde (zarontin)

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5
Q

______enhances gamma-aminobutyric acid (GABA) mediated chloride influx;shift in CL- ions results in hyperpolarization (a less excitable state) and membrane stabilization

A

Phenobarbital / primidone

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6
Q

Can only mix phenytoin with what?

A

NS.

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7
Q

Phenytoins max infusion rate is ___

A

50mg/min

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8
Q

Enteral feeding tubes may ______phenytoin absorption

A

Decrease. Must separate

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9
Q

If albumin is low (

A

Higher

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10
Q

______T-type calcium channel blocker and fast sodium channel blocker that increases GABA, an inhibitory neuron

A

Valproic acid

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11
Q

tR for valproic acid

A

50-100

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12
Q

Valproate and lamictal watch out for __

A

Rash

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13
Q

Valproate and carbapenams watch out for ___

A

Decrease valproic acid and increase risk for seizures

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14
Q

________inhibit release of glutamate and aspartate (excitatory amino acid), fast sodium channel blocker and t-type calcium channel blocker stabilizing neuronal membranes

A

Lamotrigine

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15
Q

____unknown; may inhibit voltage-dependent N type calcium channels and facilitates GABA ergic inhibitory transmission through displacement of negative modulators

A

Keppra

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16
Q

What drug interactions does Keppra have?

A

No significant ones

17
Q

_______fast sodium channel blocker stabilizing hyper excited neuronal membranes, inhibiting repetitive firing, and reducing the propagation of synaptic impulses

A

Oxcarbazepine

18
Q

Oxcarbazepine dose conversion:

A

1.2-1.5x carbamazepine dose

19
Q

Big side effect of Oxcarbazepine

A

Hypo NA Reduce dose in renal impairment

20
Q

_____has the highest risk for fetal harm in pregnancy

A

Valproate

Top 300 (30 decks)

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