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Drug Interactions Flashcards

1
Q

Inducer or inhibitor

Smoking

A

Inducer

Ps Porcs

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2
Q

Inducer or inhibitor

Phenobarbital

A

Inducer

Ps Porcs

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3
Q

Inducer or inhibitor

Oxcarbazepine

A

Inducer

Ps Porcs

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4
Q

Inducer or inhibitor

Rifampin, rifabutin, rifapentine

A

Inducer

Ps Porcs

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5
Q

Inducer or inhibitor

Carbamazepine

A

Inducer

Ps Porcs

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6
Q

Inducer or inhibitor

St. John’s wort

A

Inducer

Ps Porcs

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7
Q

Inducer or inhibitor

Grapefruit

A

Inhibitor

G-pacman

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8
Q

Inducer or inhibitor

Protease inhibitors

A

Inhibitor

G-pacman

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9
Q

Inducer or inhibitor

Azole antifungals

A

Inhibitor

G-pacman

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10
Q

Inducer or inhibitor

Cimetidine

A

Inhibitor

And androgen blocking effects that can cause gynecomastia

G-pacman

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11
Q

Inducer or inhibitor

Macrolides

A

Inhibitor-all but azithromycin is not!

G-pacman

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12
Q

Inducer or inhibitor

Amiodarone

A

Inhibitor

G-pacman

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13
Q

Inducer or inhibitor

Non-DHP CCBs

A

Inhibitor

G-pacman

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14
Q

Pgp substrates

A

Pradaxa and xarelto

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15
Q

Pgp inhibitors

A 
Cyclosporine
Ketoconazole
Itraconazole
Lopinavir/ritonavir
Ritonavir
Indinavir/ritonavir 
Conivaptan
Erythromycin
Verapamil
Quinidine
St. John's wort
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16
Q

Decrease dose by 30-50 % of using Amiodarone with these drugs

A

Digoxin, warfarin, quinidine, and procainamide

Also, just use lower doses of simvastatin, lovastatin, and atorvastatin

17
Q

Before using Amiodarone, all _______abnormalities must be fixed first!

A

Electrolyte

18
Q

Avoid using antacids with which 2 antifungals

A

Itra and ketoconazold

19
Q

Digoxin should not be used if the patient is in ______

A

Acute renal failure

20
Q

Grapefruit juice interactions

A

Lovastatin, simvastatin, atorvastatin, Amiodarone, diazepam, verapamil, nicardipine, felodipine,nifedipine, telithromycin, vori, cbz, cyclosporine, and tacrolimus

21
Q

Inducer or inhibitor

Phenytoin

A

Inducer

Ps Porcs

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