Diabetes

Question 1

Ada treatment goals

A1c
Prep randier plasma glucose
Postprabdial plasma glucose (1-2hlurs after start of meal)

Question 2

Biguanide

Answer 2

Metformin

Question 3

Meglitinide

Answer 3

Prandin (repaglinide)

Nateglinide (Starlix)

Question 4

Perixisome proliferator-activated receptor gamma (PPAR) agonists causing increased peripheral insulin sensitivity (increased uptake and utilization of glucose by the peripheral tissues; insulin sensitizers

Answer 4

Thiazolidinediones (TZDs)

Question 5

Rems program for which diabetic drug?

Answer 5

Rosiglitazone (Avandia)

Question 6

Take actos with food?

Answer 6

With or without food

Question 7

Alpha- glycosidase inhibitors

Answer 7

Acarbose (Precose)

Miglitol (Glyset)

Question 8

These agents inhibit alpha-glycosidase in the intestines resulting in delayed absorption of glucose. They also inhib metabolism of sucrose to glucose and fructose and inhibit pancreatic enzymes which delay the digestion of starch

Answer 8

Alpha-glucosodase inhibitors

Question 9

When do you take a acarabosr?

Answer 9

With first bite of meal

Question 10

If you get low Bs with acarabosr, you can’t treat it with what? Only with what?

Answer 10

Sucrose (present in fruit juices)

Only with oral glucose tablets or gels

Question 11

Prevent the enzymes from breaking down incretin hormones, glucagon-like peptide and glucose -dependent insilinotropi polypeptide. Incretin enhancers

Answer 11

Dpp4- inhibitors

Question 12

Dpp4 inhibitors

Answer 12

Sitagliptin (januvia)
Saxagliptin (onglyza)
Linagliptin (tradjenta)

Question 13

Synthetic analog of the human neuroendocrine hormone, amylin. Amylin helps slow gastric emptying which increases satiety

Answer 13

Pramlintide

Question 14

Pramlintide can be used in both type 1 and type 2 dm. True or false

Answer 14

True

Question 15

Patients on amylin and insulin should do what?

Answer 15

Decrease insulin dose by 50%. Warn and watch for hypoglycemia 3 hours later

Question 16

What is the typical initiating insulin starting dose?

Answer 16

O.6 units/kg/day

Question 17

How to mix insulins?

Answer 17

Clear before cloudy

Question 18

500/TDD=

Answer 18

Grams of carbohydrate covered by 1 unit of insulin

Question 19

Correction factor =

Answer 19

1800/TDD

Question 20

Correction Dose =

Answer 20

((Blood glucose now)-(target blood glucose)) / correction factor

Question 21

Which insulins are FDA approved for treatment of gestational dm?

Answer 21

NPH and regular. Metformin is ok as well. Glyburide can’t be used in first trimester.