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step 1 pharm > seizure drugs > Flashcards

seizure drugs Flashcards

1
Q

first line for absence seizures

A

ethosuximide

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2
Q

ethosuximide moa

A

blocks T-type Ca channels

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3
Q

ethosuximide adverse effects

A

stevens-Johnson syndrome; itching

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4
Q

first line for status epilepticus

A

benzodiazepines (lorazepam, diazepam)

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5
Q

phenytoin moa

A

sodium channel inactivation

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6
Q

phenytoin pharmacokinetics

A

zero order elimination

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7
Q

phenytoin adverse effects

A

gingival hyperplasia, hirsutism, ataxia, SLE-like syndrome, Stevens-Johnson syndrome, osteopenia, megaloblastic anemia; teratogen - causes fetal hydantoin syndrome (clef lip, palate, congenital heart disease, and developmental delay)

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8
Q

drugs for tonic clonic seizures

A

valproic acid, carbamazepine, and phenytoin

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9
Q

carbamazepine moa

A

Na channel inactivation

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10
Q

carbamazepine adverse effects

A

agranulocytosis, aplastic anemia, SIADH, hepatotoxicity, SJS, teratogenic

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11
Q

seizure drugs that induce CYPs

A

phenytoin and carbamazepine

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12
Q

1st line for trigeminal neuralgia

A

carbamazepine

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13
Q

valproic acid moa

A

sodium channel inactivation and increases GABA concentration by inhibiting GABA transaminase

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14
Q

valproic acid adverse effects

A

hepatotoxicity, neural tube defects in pregnancy

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15
Q

first line for complex seizures

A

carbamazepine

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16
Q

first line for simple seizures

A

carbamazepine

17
Q

gabapentin moa

A

inhibits voltage gated calcium channels; GABA analog

18
Q

topiramate moa

A

blocks Na channels; increases GABA action

19
Q

topiramate adverse effects

A

kidney stones and weight loss

20
Q

lamotrigine moa

A

blocks Na channels

21
Q

lamotrigine adverse effects

A

stevens johnson syndrome

22
Q

levetiracetam moa

A

unknown; may modulate GABA and glutamate release

23
Q

tiagabine moa

A

increases GABA by inhibiting re-uptake

24
Q

vigabatrin moa

A

increases GABA by irreversible inhibiting GABA transaminase

step 1 pharm (20 decks)

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