immunosuppressants

Question 1

cyclosporine moa

Answer 1

binds cyclophilin and inhibits calcineurin; blocks T cell activation by preventing IL-2 transcription

Question 2

cyclosporine toxicity

Answer 2

nephrotoxicity, hypertension, hyperlipidemia, hyperglycemia, tremor, hirsutism, gingival hyperplasia

Question 3

tacrolimus moa

Answer 3

binds FKBP and inhibits calcineurin; blocks T cell activation by preventing IL-2 transcription

Question 4

tacrolimus toxicity

Answer 4

nephrotoxicity, high risk of DM and neurotoxicity

Question 5

sirolimus moa

Answer 5

binds FKBP and inhibition mTOR; blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction (IL-2 is there and can bind, the cells just dong respond to it)

Question 6

sirolimus toxicity

Answer 6

anemia, thrombocytopenia, leukopenia, insulin resistance, hyperlipidemia; non-nephrotoxic

Question 7

basaliximab moa

Answer 7

mAb to IL-2R

Question 8

basaliximab toxicity

Answer 8

edema, HTN, tremor

Question 9

azathioprine moa

Answer 9

antimetabolite precursor of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis

Question 10

azathioprine toxicity

Answer 10

leukopenia, anemia, thrombocytopenia

Question 11

glucocorticoid moa

Answer 11

inhibit NFkB; suppresses both B and T cell function by decreasing transcription of many cytokines

Question 12

glucocorticoid toxicity

Answer 12

hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychosis, acne, HTN, cataracts, peptic ulcers

Question 13

mycophenolate moa

Answer 13

inhibits IMP-dehydrogenase, preventing guanine synthesis; prevents rapid B and T cell proliferation

Question 14

thalidomide moa

Answer 14

affects TNF alpha

Question 15

thalidomide toxicity

Answer 15

phocomelia in fetus