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step 1 pharm > drug reactions > Flashcards

drug reactions Flashcards

1
Q

coronary vasospasm

A

cocaine, sumatriptan, ergot alkaloids, amphetamine

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2
Q

cutaneous flushing

A

vancomycin, adenosine, niacin, Ca channel blockers

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3
Q

dilated cardiomyopathy

A

doxorubicin, daunorubicin

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4
Q

torsades de pointes

A

class III (e.g. sotalol) and class IA (e.g. quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics (haloperidol), and TCAs

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5
Q

adrenocortical insufficiency

A

abrupt glucocorticoid withdrawal

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6
Q

hot flashes

A

tamoxifen, clomiphene (SERMs)

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7
Q

hyperglycemia

A

tacrolimus, protease inhibitors, niacin, HCTZ, beta-blockers

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8
Q

hypothyroidism

A

lithium, amiodarone, sulfonamides

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9
Q

gynecomastia

A

ketoconazole, estrogens, spironolactone

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10
Q

acute cholestatic hepatitis, jaundice

A

erythromycin

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11
Q

diarrhea

A

metformin, erythromycin, colchicine, orlistat, acarbose

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12
Q

focal to massive hepatic necrosis

A

halothane, valproic acid, acetaminophen

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13
Q

hepatitis

A

Isoniazid

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14
Q

pancreatitis

A

didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics

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15
Q

pseudomembranous colitis

A

clindamycin, ampicillin, cephalosporins

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16
Q

agranulocytosis

A

dapsone, clozapine, carbamazepine, colchicine, methimazole, PTU

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17
Q

aplastic anemia

A

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, PTU

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18
Q

direct coombs + hemolytic anemia

A

methyldopa, penicillin

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19
Q

grey baby syndrome

A

chloramphenicol

20
Q

hemolysis in G6PD deficiency

A

INH, Sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin, fava beans

21
Q

megaloblastic anemia

A

phenytoin, methotrexate, sulfa drugs

22
Q

thrombocytopenia

A

heparin, cimetidine

23
Q

thrombotic complications

A

OCPs (estrogens)

24
Q

fat redistribution

A

protease inhibitors, steroids

25
Q

gingival hyperplasia

A

phenytoin, verapamil, cyclosporine, nifedipine

26
Q

hyperuricemia (gout)

A

pyrazinamide, thiazides, furosemide, niacin, cyclosporine

27
Q

myopathy

A

Fibrates, niacin, colchicine, hydroxychloroquine, IFN-alpha, penicillamine, statins, steroids

28
Q

osteoporosis

A

corticosteroids, heparin

29
Q

photosensitivity

A

sulfonamides, amiodarone, tetracyclines, 5-FU

30
Q

stevens-Johnson

A

anti epileptic drugs, allopurinol, sulfa drugs, penicillin

31
Q

SLE-like syndrome

A

sulfa-drugs, hydrazine, INH, procainamide,

32
Q

teeth discoloration

A

tetracyclines

33
Q

tendonitis, rupture

A

fluoroquinolones

34
Q

cinchonism (dizziness, HA, vision changes, tinnitus)

A

quinidine, quinine

35
Q

parkinson-like syndrome

A

antipsychotics, reserpine, metoclopramide

36
Q

seizures

A

isoniazid (due to B6 deficiency), bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

37
Q

tardive dyskinesia

A

antipsychotics, metoclopramide

38
Q

diabetes insipidus

A

lithium, demeclocylcine

39
Q

fanconi syndrome

A

expired tetracycline

40
Q

hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

41
Q

interstitial nephritis

A

methicillin, NSAIDs, furosemide

42
Q

SIADH

A

carbamazepine, cyclophosphamide, SSRIs

43
Q

cough

A

ACE inhibitors

44
Q

pulmonary fibrosis

A

bleomycin, amiodarone, busulfan, methotrexate

45
Q

disulfiram- like reactions

A

disulfiram, metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st gen. sulfonylureas

46
Q

nephrotoxicity/ototoxicity

A

aminoglycosides, vancomycin, loop diuretics, cisplatin

step 1 pharm (20 decks)

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