Segars - Hormonal Contraceptives Flashcards
Most common entity in HC
Ethinyl estradiol
Gonanes
Levonorgestrel, norgestrel, norgestimate, desogestrel, dienogest
Estranes
Ethynodiol diacetate, northindrone, norethindrone acetate
Receptor effects of gonanes
Progestinic & androgenic (except for dienogest)
Fixed dose of estrogen and progestin throughout cycle
Monophasic HC
Fixed dose of estrogen; lower progestin in first half of cycle with increased amount in second half
Biphasic HC
Increasing dose of estrogen (or progestin) 3x during the cycle
Triphasic HC
Decreasing dose of estrogen and increasing amounts of progestin 4x during cycle
Quadriphasic HC
Patch with EE, 7 day duraton
Norelgestromin
Vaginal ring with EE, 3 week duration
Etomogestrel
Available as progestin only implantable rod, 3 yr duration
Etonogestrel
Progestin only, long acting depo injection, 3 mo duration
Medroxyprogesterone
Progestin only IUD, available as 3 or 5 year device
Levonorgestrel
4 reducing non-contraceptive effects of estrogen
Cholesterol, AT-III, osteoclastic activity, bile acid levels
Pharm effects of HC
Modify LH & FSH surges