Fitz - Male UG Disorders

Question 1

Converts testosterone to estradiol

Answer 1

Aromatse

Question 2

GnRH/LHRH antagonist

Answer 2

Degarlix

Question 3

GnRH/LHRH agonists

Answer 3

Leuprolide, nafarelin (nasal)

Question 4

Natural version of GnRH/LHRH

Answer 4

Gonadorelin

Question 5

Only drug in US approved to tx advanced prostate cancer

Answer 5

Degarelix

Question 6

Causes desensitization of GnRH and LH receptors after continued admin

Answer 6

Leuprolide

Question 7

Leuprolide initially causes

Answer 7

T surge!

Question 8

Worry about leuprolide flare in pts who

Answer 8

Have ca that has met to bone

Question 9

Maganement of leurprolide flair with

Answer 9

Androgen receptor antagonists

Question 10

Androgen receptor antagonists

Answer 10

Bicalutamide, flutamide, nilutamide

Question 11

MCly used androgen receptor antatgonist

Answer 11

Biclutamide

Question 12

Drugs used in targets androgen biosythesis disruption

Answer 12

Abirateron, ketoconazole

Question 13

Blocks CYP17 to lower tumor production of androgens

Answer 13

Abiraterone

Question 14

Abiraterone must be used with

Answer 14

Prednisone or other corticosteroid

Question 15

AEs: abiraterone alone

Answer 15

Cortisol depletion, aldoseterone enhancement

Question 16

AE: ketokonazole

Answer 16

Hepatotoxicity

Question 17

Inhibitors of 5alpha-reductase

Answer 17

Finasteride, dutasteride

Question 18

Tx of male infertility

Answer 18

hCG

Question 19

hCG is an analogue of

Answer 19

LH

Question 20

SERM used in secondary hypogonadism

Answer 20

Clomiphene

Question 21

Aromatase inhibitors in secondary hypogonadism

Answer 21

Anatrazole, letrazole

Question 22

Enzyme that makes DHT from testosterone

Answer 22

5alpha reductase