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Repro II > Robbins Ch 22 - Lecture 1 > Flashcards

Robbins Ch 22 - Lecture 1 Flashcards

1
Q

Active HSV infection in mother during delivery usually warrants a

A

Cesarean section

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2
Q

HSV2 infection enhances aquisition and transmission of t

A

HIV-1

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3
Q

Time period that HSV can be detected and serotyped

A

48-72 hrs post infection

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4
Q

MC sexually transmitted strain of molluscum contagiosum

A

MCV-2

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5
Q

MC strain of molluscum contagiosum

A

MCV-1

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6
Q

Incubation period of molluscum contagiosum

A

6 wks

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7
Q

Pearly, dome shared papules with dimpled center

A

Molluscum contagiosum

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8
Q

Vulvovaginal puritis, erythema, swelling, curd like vaginal discharge

A

Yeast infection

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9
Q

Pseudospores or filament oust fungal hyphae in wet KOH mount or on Pap smear

A

Yeast infection

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10
Q

Flange, flagellated ovoid protazoan

A

Trichomonas vaginalis

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11
Q

Trichomonas vaginalis infection develops within

A

4d to 4w

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12
Q

Yellow, frothy, vaginal discharge

A

Trichomoas vaginalis

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13
Q

Fiery-red, “strawberry cervix”

A

Tri homonyms vaginalis

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14
Q

Gerdnerella vaginalis morphology

A

Gram-negative bacillus

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15
Q

Thin, green gray malodorous discharge

A

Gardenerlla vaginalis

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16
Q

Superficial and intermediate squamous cells covered with a shaggy coating coccobacillus

A

Gardenerla vaginalis

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17
Q

Main cause of bacterial vaginosis

A

Gardeneralla vaginalis

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18
Q

G. Vaginalis in pregnancy can induce

A

Premature labor

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19
Q

Implicated in choroamnionitis and premature delivery in pregnancy pts

A

Ureaplasma urealyticum, mycoplasma hominis

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20
Q

Infections mainly take form of cervicits but may ascend to result in endometritis and salpingitis

A

Chalmydia trachomatis

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21
Q

Most serious complication of gohorrhea in woman

A

PID

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22
Q

Infection that begins in the vulva or vagina and spreads upward to involve most structures in the female genial system

A

PID

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23
Q

Pelvic pain, adnexal tenderness, fever, vaginal discharge

A

PID

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24
Q

PID with less involvement of the mucosa and tube lumen and more inflammation within the deeper tissue layers is cause by

A

Staph, streptococci, coliforms and cholstridium prefringens (non-gonococcal)

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25
Q

Multinucleacted cells, intranuclear viral inclusions, “ground-glass” appearance

A

HSV infection

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26
Q

Smooth white plaques or macules that may coalesce that can cause atrophy or agglutination of the vulva and may cause vaginal orifice constriction

A

Lichen sclerosus

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27
Q

Marked thinning of vulva epidermis, degeneration of basal cells, hyperkeratosis, sclerotic changes of dermis, bandlike lymphocytic infiltrate underlying the dermis

A

Lichen sclerosis

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28
Q

Lichen sclerosis sligtly increasea risk of developing

A

Sq cell carcinoma of the vulva

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29
Q

Result of rubbing or scratching vulva skin w/ leukoplakia, acanthosis, and hyperkeratosis

A

Sq cell hyperplasia

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30
Q

Benign genital warts cause by low oncogenic risk HPVs

A

Condylomata acuminatum

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31
Q

MC HPV strains that cause Condylomata acuminatum

32
Q

Papillary, exophytic treelike cores of stroma covered by thickened squamous epi. ith koilocytic atypia seen on surface epi

A

Condylomata acuminatum

33
Q

Nuclear enlargement, hyperchomasia, cytoplasmic perinuclear halo

A

Koilocytic atypia, characteristic of Condylomata acuminatum

34
Q

MC histologic type of vulvar cancer

A

Squamous cell

35
Q

Vulvular carinoma MCly seen in younger women d/t HPV-16

A

Basaloid and warty carcinomas

36
Q

MC vulvar carinoma seen in older women - 70% ass’d with HPV inf

A

Keratinizing sq cell carcinoma

37
Q

Classic vulvar intraepithelial neoplasia (VIN)

A

Basaloid and warty carcinomas

38
Q

Peak age for basaloid or warty vulvar cancer

A

6th decade

39
Q

Ass’d with long standing lichen slerosis or sq cell hyperplasia - not related to HPV

A

Keratinizing sq cell carcinoma of vulva

40
Q

Peak age of keratinizing sq cell carcinoma of vulva

A

8th decade

41
Q

VIN simplex or differentiated VIN

A

Keritinizing sq cell carcinoma

42
Q

scarring and fusion of plicae

A

chronic salpingitis

43
Q

acute complications of PID

A

peritonitis and bacteremia

44
Q

chronic complications of PID

A

infertility and tubal obstruction

45
Q

Nests and cords or small, tightly paked cells that lack matuation and resemble the basal layer of normal epi

A

Basaloid carcinoma

46
Q

Exophytic papillary architecture and prominent kiolcytic atypia

A

Warty carcinoma

47
Q

Sharply circumscribed nodule, MCly on the labia majora or interlabial folds

A

Papillary hidradenoma

48
Q

Papillary projections w/ 2 layers: upper layer of columnar secretory cells, deeper layer of flattened myoepithelial cells

A

Papillary hidradenoma

49
Q

Puritic, red, crusted, maplike area, usually on the labia majora

A

Extramammary paget disease

50
Q

Immunostain for cytokeratin 7

A

Paget cells

51
Q

Failure of mullerian duct fusion leads to

A

Double vagina and double uterus

52
Q

Red, granular areas made of up columnar, mucinous epi found in the vagina

A

Vaginal adenosis

53
Q

Fluid-filled cysts found on the lateral walls of the vagina that are derived from woffian duct rests

A

Gartner duct cysts

54
Q

Virtually all primary carcinomas of the vagina are

A

Sq cell carcinomas, ass’d with high risk HPV

55
Q

Greatest risk factor for developing sq cell carcinoma of the vagina

A

Previous carcinoma of the cervix or vulva

56
Q

Vaginal intraepithelial neoplasia

A

Premalignant lesion to sq cell ca of the vagina

57
Q

Age group of embryonal rhabdomyosarcoma pts

A

Infants and childre

58
Q

Grape-like, polypoid mass protruding from the vagina

A

embryonal rhabdomyosarcoma

59
Q

Oval nuclei with small protrusions of cytoplasm, look like tennis rackets

A

embryonal rhabdomyosarcoma

60
Q

Loose fibromyxomatous stroma covered by mucus-secreting endo cervical glands, often accompanied by inflammation

A

Endocervical polyps

61
Q

In the cervix, HPV infects

A
  • immature basal cells of the sq epi in areas of epi breaks

- metaplastic sq cells at the squamocolumnar junction

62
Q

Viral proteins of HPV responsible for carcinogenic capabilities

63
Q

Binds hypophosphorlyated form of RB and promotes its degresdation , and inhibits p21 and p27

A

Viral protein E7

64
Q

Binds p53 and promotes it’s degradation, upregulates telomerase

A

Viral protein E6

65
Q

High level of viral replication, mild alterations in the growth of host cells, most cases regress spontaneously

66
Q

Progressive dysregulation of the cell cycle, increased cellular proliferation, decreased/arrested epi maturation, lower rate of viral replication, high risk of progression to carcinoma

67
Q

Nuclear enlargement, hyperchromasia, coarse chromatin granules, variation in nuclear size and shape

68
Q

Ki-67 and p16 staining

A

areas of high mitotic activity

69
Q

Nests and tongues of malignant sq epi breaking though the basement membane and invading the underlying cervical stroma

A

Sq cell carcinoma of the cervix

70
Q

Proliferation of glandular epi composed of malignant endocervical cells with large, hyperchromatic nuclei with mucin-depleted cytoplasm

A

Adenocarcinoma of the cervix

71
Q

Woman >30 yo w/out HPV and normal cytology should be screened

A

Every 5 yr

72
Q

Women with normal cytology but are positive for high-risk HPV should have cervical cytology every

73
Q

low risk (oncogenic) HPV types

74
Q

DES exposure

A

adenosis of the vagina

75
Q

lymph from vulva and distal 1/3 vagina drains to

A

inguinal nodes

76
Q

lymph from proximal 2/3 vagina and uterus drains to

A

iliac (internal) nodes

Repro II (12 decks)

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