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Repro II > Robbins Ch 22 - Lecture 3 > Flashcards

Robbins Ch 22 - Lecture 3 Flashcards

1
Q

Large translucent cysts found near the end of the falopian tubes or in the broad ligament

A

Hydatids of Morgagni

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2
Q

Hyperandrogenism, mensutral abnormalities, polycystic ovaries, chonic anovulation, decreased fertility

A

Polycytic ovarian syndrome (PCOS)

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3
Q

Women with PCOS are at a higher risk of endometrial carcinoma d/t increased

A

Estrone levels

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4
Q

Uniform enlargement of the ovary (usually b/l), hypercellular stroma w/ lutinization that appear as discrete nests of cells with vacuolated cytoplasm; MC in postmenopausal F

A

Stromal hyperthecosis

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5
Q

Recently pregnant F with concentric, theca-lutein hyperplasia and nodularity of the ovaries

A

Theca lutein hyperplasia of preganancy

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6
Q

MC malignant ovarian tumors

A

Serous tumors

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7
Q

BRCA 1 and 2

A

Increased susceptibility to ovarian cancer

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8
Q

Arise form in situ lesions in the fallopian tube fimbriae or from serous inclusions cysts within ovaries

A

High-grade serous carcinomas

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9
Q

KRAS, BRAF, ERBB2 mutations are ass’d with

A

Low-grade serous ovarian tumors

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10
Q

In comparison to low-grade serous carciomas, high-grade have

A

More complex growth patterns and widespread infiltration of effacement of underlying stroma

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11
Q

nonspecific histologic character of serous tumors

A

Psammoma bodies

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12
Q

MC infections leading to supperative salpingitis

A

Gonococcus and chlamydiae

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13
Q

Mutation of what gene is a consistent alteration in mucinous tumors?

A

KRAS

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14
Q

Tall columnar epi lining with apical mucin that lacks cilia, can see gastric or intestinal type differentiation

A

Mucinous tumor

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15
Q

Mucinous carcinomas characteristically demonstrate

A

Confluent glandular growth

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16
Q

Extensive mucinous ascites, cystic epithelial impants on the peritoneal surface, adhesions, frequent involvement of the ovaries

A

Pseudomyxoma peritonei

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17
Q

PI3K/AKT increased signaling, mutations in CTNNB1 and mismatch DNA repair genes are found in what type of ovarian cancer?

A

Endometrioid ovarian cancer

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18
Q

Clear cells arranged in sheets or tubules

A

Solid clear cell neoplasm

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19
Q

Clear cells lining cystic spaces

A

Cystic clear cell carcinoma

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20
Q

Small, multiloculated mass in the ovary with pronounced proliferation of fibrous stroma underlying columnar epi with simple papillary architecture

A

Cysadenofibroma

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21
Q

Tumor of the ovary with cells that resemble urothelium

A

Transitional cell tumor

22
Q

Another name for transitional cell tumors

A

Brenner tumor

23
Q

Transitional cell carcinomas of the ovary consist of

A

> 50% malignant transitional type epi

24
Q

Used to monitor disease recurrence and progression in ovarian epithelial tumors

25
Q

Unilocular cyst containing hair, sebaceous material, tooth structures, bone, cartialge, thyroid, and areas of calcification

A

Benign (mature) teratomas

26
Q

Mature teratomas rarely transform into

A

Sq cell ca

27
Q

Karyotype of almost all benign teratomas

28
Q

Teratoma composed of mature thyroid tissue that can cause hyperthyroidism

A

Struma ovarii

29
Q

Teratoma that can produce 5-hydroxytryptamine

A

Ovarian carcinoid

30
Q

Bulky smooth tumor externally with hair, sebaceous material, bone, calcifications, and immature neuropeithelium with necrosis and hemorrhage on sectioning

A

Immature malignant teratomas

31
Q

OCT-3, OCT4, NANOG, KIT mutations

A

Ovarian dysgerminoma

32
Q

Yello-white to gray-pink appearance on cut surface, large vesicular cells with clear cytoplasm, well-defined cell boundaries, and centrally placed regular nuclei

A

Dysgerminoma

33
Q

Elaboration of alpha-fetoprotein

A

Yolk sac tumor

34
Q

Shiller-duval body

A

Yolk sac tumor

35
Q

Glomerulus like structure with central blood vesssels envelped by turmor cells within a space that is also lined by tumor cells

A

Shiller-duval body

36
Q

Elaborates high levels of chorionic gonadotropin

A

Chroniocarcinoma

37
Q

Small, distinctive, gland-like structures filled with acidophilic material

A

Call-exner bodies, granulosa cell tumors

38
Q

Granulosa cell tumors may elaborate ____________ and may behave like ___________________.

A

Estrogen, low-grade malignancies

39
Q

Granulosa cell tumors with yellow coloration is ML

A

Hormonally acive

40
Q

Elevates tissue and serum levels of inhibin are ass’d with

A

Granulosa cell tumors

41
Q

FOXL2

A

Adult granulosa cell tumors

42
Q

Tumor with mix of fibroblasts and spindle cells with liquid droplets

A

Fibrothecomas

43
Q

White-gray firm mass covered by ovaraian serosa and is composed of well-differentiated fibroblasts and scant stroma on histo

44
Q

Ovarian tumor, hydrothorax, ascites

A

Meigs syndrome

45
Q

Tumors that can cause masculinization or defeminization

A

Sertoli-leydig tumors

46
Q

DICER1 mutations

A

Sertoli-leydig cell tumors

47
Q

Clusters of polygonal cells arranged around hilar vessels; masulinization of F

A

Hilus cell tumor (pure leydig)

48
Q

Tumor that resembles the corporus luemu of pregnancy

A

Pregnancy luteoma

49
Q

MC sex cord-stromal tumor

A

Granulosa cell tumor

50
Q

MC neoplasms that met to the ovary

A

Breast and GI - colon, stomach, biliary, pancreas

51
Q

GI metastatic carcinoma that is composed of mucin-producing, signet-ring cell cancers that mets to the ovary

A

Krukenberg tumor

Repro II (12 decks)

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