Robbins Ch 22 - Lecture 3

Question 1

Large translucent cysts found near the end of the falopian tubes or in the broad ligament

Answer 1

Hydatids of Morgagni

Question 2

Hyperandrogenism, mensutral abnormalities, polycystic ovaries, chonic anovulation, decreased fertility

Answer 2

Polycytic ovarian syndrome (PCOS)

Question 3

Women with PCOS are at a higher risk of endometrial carcinoma d/t increased

Answer 3

Estrone levels

Question 4

Uniform enlargement of the ovary (usually b/l), hypercellular stroma w/ lutinization that appear as discrete nests of cells with vacuolated cytoplasm; MC in postmenopausal F

Answer 4

Stromal hyperthecosis

Question 5

Recently pregnant F with concentric, theca-lutein hyperplasia and nodularity of the ovaries

Answer 5

Theca lutein hyperplasia of preganancy

Question 6

MC malignant ovarian tumors

Answer 6

Serous tumors

Question 7

BRCA 1 and 2

Answer 7

Increased susceptibility to ovarian cancer

Question 8

Arise form in situ lesions in the fallopian tube fimbriae or from serous inclusions cysts within ovaries

Answer 8

High-grade serous carcinomas

Question 9

KRAS, BRAF, ERBB2 mutations are ass’d with

Answer 9

Low-grade serous ovarian tumors

Question 10

In comparison to low-grade serous carciomas, high-grade have

Answer 10

More complex growth patterns and widespread infiltration of effacement of underlying stroma

Question 11

nonspecific histologic character of serous tumors

Answer 11

Psammoma bodies

Question 12

MC infections leading to supperative salpingitis

Answer 12

Gonococcus and chlamydiae

Question 13

Mutation of what gene is a consistent alteration in mucinous tumors?

Answer 13

KRAS

Question 14

Tall columnar epi lining with apical mucin that lacks cilia, can see gastric or intestinal type differentiation

Answer 14

Mucinous tumor

Question 15

Mucinous carcinomas characteristically demonstrate

Answer 15

Confluent glandular growth

Question 16

Extensive mucinous ascites, cystic epithelial impants on the peritoneal surface, adhesions, frequent involvement of the ovaries

Answer 16

Pseudomyxoma peritonei

Question 17

PI3K/AKT increased signaling, mutations in CTNNB1 and mismatch DNA repair genes are found in what type of ovarian cancer?

Answer 17

Endometrioid ovarian cancer

Question 18

Clear cells arranged in sheets or tubules

Answer 18

Solid clear cell neoplasm

Question 19

Clear cells lining cystic spaces

Answer 19

Cystic clear cell carcinoma

Question 20

Small, multiloculated mass in the ovary with pronounced proliferation of fibrous stroma underlying columnar epi with simple papillary architecture

Answer 20

Cysadenofibroma

Question 21

Tumor of the ovary with cells that resemble urothelium

Answer 21

Transitional cell tumor

Question 22

Another name for transitional cell tumors

Answer 22

Brenner tumor

Question 23

Transitional cell carcinomas of the ovary consist of

Answer 23

> 50% malignant transitional type epi

Question 24

Used to monitor disease recurrence and progression in ovarian epithelial tumors

Answer 24

CA-125

Question 25

Unilocular cyst containing hair, sebaceous material, tooth structures, bone, cartialge, thyroid, and areas of calcification

Answer 25

Benign (mature) teratomas

Question 26

Mature teratomas rarely transform into

Answer 26

Sq cell ca

Question 27

Karyotype of almost all benign teratomas

Answer 27

46 XX

Question 28

Teratoma composed of mature thyroid tissue that can cause hyperthyroidism

Answer 28

Struma ovarii

Question 29

Teratoma that can produce 5-hydroxytryptamine

Answer 29

Ovarian carcinoid

Question 30

Bulky smooth tumor externally with hair, sebaceous material, bone, calcifications, and immature neuropeithelium with necrosis and hemorrhage on sectioning

Answer 30

Immature malignant teratomas

Question 31

OCT-3, OCT4, NANOG, KIT mutations

Answer 31

Ovarian dysgerminoma

Question 32

Yello-white to gray-pink appearance on cut surface, large vesicular cells with clear cytoplasm, well-defined cell boundaries, and centrally placed regular nuclei

Answer 32

Dysgerminoma

Question 33

Elaboration of alpha-fetoprotein

Answer 33

Yolk sac tumor

Question 34

Shiller-duval body

Answer 34

Yolk sac tumor

Question 35

Glomerulus like structure with central blood vesssels envelped by turmor cells within a space that is also lined by tumor cells

Answer 35

Shiller-duval body

Question 36

Elaborates high levels of chorionic gonadotropin

Answer 36

Chroniocarcinoma

Question 37

Small, distinctive, gland-like structures filled with acidophilic material

Answer 37

Call-exner bodies, granulosa cell tumors

Question 38

Granulosa cell tumors may elaborate ____________ and may behave like ___________________.

Answer 38

Estrogen, low-grade malignancies

Question 39

Granulosa cell tumors with yellow coloration is ML

Answer 39

Hormonally acive

Question 40

Elevates tissue and serum levels of inhibin are ass'd with

Answer 40

Granulosa cell tumors

Question 41

FOXL2

Answer 41

Adult granulosa cell tumors

Question 42

Tumor with mix of fibroblasts and spindle cells with liquid droplets

Answer 42

Fibrothecomas

Question 43

White-gray firm mass covered by ovaraian serosa and is composed of well-differentiated fibroblasts and scant stroma on histo

Answer 43

Fibromas

Question 44

Ovarian tumor, hydrothorax, ascites

Answer 44

Meigs syndrome

Question 45

Tumors that can cause masculinization or defeminization

Answer 45

Sertoli-leydig tumors

Question 46

DICER1 mutations

Answer 46

Sertoli-leydig cell tumors

Question 47

Clusters of polygonal cells arranged around hilar vessels; masulinization of F

Answer 47

Hilus cell tumor (pure leydig)

Question 48

Tumor that resembles the corporus luemu of pregnancy

Answer 48

Pregnancy luteoma

Question 49

MC sex cord-stromal tumor

Answer 49

Granulosa cell tumor

Question 50

MC neoplasms that met to the ovary

Answer 50

Breast and GI - colon, stomach, biliary, pancreas

Question 51

GI metastatic carcinoma that is composed of mucin-producing, signet-ring cell cancers that mets to the ovary

Answer 51

Krukenberg tumor