Robbins Ch 22 - Lecture 2

Question 1

shedding of the functionalis

Answer 1

menses

Question 2

straight tubular glands line with regular, tall pseudostratified columnar cells w/ no evidence of mucus secretion or vacuolation

Answer 2

proliferative phase

Question 3

appearance of secretory vacuoles beneath the nuclei in the gladular epi

Answer 3

postovulation

Question 4

spiral arterioles, increase in ground substance and edema btwn stromal cells

Answer 4

late secretory phase

Question 5

predecidual change occurs in the

Answer 5

late secretory phase

Question 6

drives the prolideration of both glands and strom

Answer 6

estrogen

Question 7

down-regulates expression of estrogen receptor in glands and stroma

Answer 7

progesterone

Question 8

causes differentiation of the glands and function changes in stromal cells

Answer 8

progesterone

Question 9

most frequent cause of dysfunctional uterine bleeding

Answer 9

anovulation

Question 10

stromal condensation, eosinophilic epithelial metaplasia w/out glandular secretory changes and stromal pre-decicualization

Answer 10

anovulation

Question 11

infertility ass’d with increased bleeding or amenorrhea d/t inadequate progesterone production during post-ovulatory period

Answer 11

inadequate luteal phase

Question 12

acute endometritis is caused by

Answer 12

GAS, staphlyococci or another bacteria post delivery or miscarriage

Question 13

ectopic endometrial tisse at a site outside of the uterus

Answer 13

endometriosis

Question 14

5 MC sites of endometriosis

Answer 14

ovaries> uterine ligaments > rectovaginal septum > cul de sac > pelvic peritoneum

Question 15

MC age group of endometriosis

Answer 15

active reproductive age - 3rd/4th decade

Question 16

endometric implants in endometreosis show

Answer 16

release of proinflammatory factors, increased estrogen production by stromal cells

Question 17

genetic changes in endmetriosis indicating possible clear cell ovarian cancer

Answer 17

PTEN, ARID1A

Question 18

chocolate cysts

Answer 18

endometriosis that has cause fibrosis of the ovaries

Question 19

presence of endometiral tissues within the uertine wall

Answer 19

adenomyosis

Question 20

endometrial polyps have been ass’d with

Answer 20

tamoxifen

Question 21

important cause of abnormal bleeding and frequent precursor to MC type of endometrial carcinoma

Answer 21

endometrial hyperplasia

Question 22

inactivation of PTEN tumor suppressor in common genetic alteration in

Answer 22

endometrial hyperplasia and carcinoma

Question 23

ass’ with prolonged estrogenic stimulation of the endometrium

Answer 23

endometrial hyperplasia

Question 24

WHO classifications of endometrial hyperplasia

Answer 24

non-atypical and atypical hyperplasia

Question 25

most common mutation acts to increase signaling though the PI3K/AKT pathway

Answer 25

hallmark of type 1 endometeroid carcinoma

Question 26

clinical settings of type 1 endometrial carcinoma (4)

Answer 26

unopposed estrogen, obesity, HTN, DM

Question 27

DNA mismatch repair gene defects

Answer 27

endometrial carcinomas in women with fam hx of HNPCC

Question 28

well differentiated tumors may be distinguised from hyperplasias by

Answer 28

lack of intervening stroma

Question 29

carcinoma that is confined to the corpus uteri

Answer 29

stage I

Question 30

carcinoma that involves the corpus and cervix

Answer 30

stage II

Question 31

carcinoma that extends outside the uterus but not outside the true pelvis

Answer 31

stage III

Question 32

carcinoma that extends outside the true pelvis or involved the mucosa of the bladder and rectum

Answer 32

stage IV

Question 33

usually arise in the setting of endometrial atrophy

Answer 33

type II endometrial carcinoma

Question 34

most common subtype of type II endometrial carcinoma

Answer 34

serous carcinoma

Question 35

most prevalent mutation in type II endometrial carcinomas

Answer 35

TP53

Question 36

PI3K and PP2A mutations are also common in

Answer 36

type II endometrial carcinoma

Question 37

precursor liesion of type II endometrial carcinoma

Answer 37

serous endometrial intraepithelial carcinoma

Question 38

peak incidence of endometrial carcinomas

Answer 38

postmenopausal F, 55-65yo

Question 39

endometrial adenocarcinomas with a malignant mesenchymal component

Answer 39

malignant mixed mullerian tumors

Question 40

MMMT mets usually only contain

Answer 40

epithelial components

Question 41

bulky polypoid mass that may protude out of the cervical os composed of both malignant epi and stromal components

Answer 41

MMMT

Question 42

large, broad-based endometrial polypoid growth with malignant-appearing stroma coexisting with benign, abnormally shaped endometrial glands

Answer 42

adenosarcoma of the endometrium

Question 43

estrogen-sensitive and responds to oophorectomy

Answer 43

adenosarcoma of the endometrium

Question 44

JAZF1 SUZ12 translocation

Answer 44

low-grade endometrial stromal sarcoma

Question 45

12q14 and p6 rearrangements

Answer 45

uterine lieomyoma

Question 46

well differentiated, regular, spindle-shaped smooth mm cells ass'd with hyalinization

Answer 46

leiomyoma

Question 47

rare variant leiomyoma that extends into vessels and can spread to other sites - MCly the lung

Answer 47

benign metastasizing leiomyoma

Question 48

dissmeniated peritoneal leiomyomatosis presents as

Answer 48

multiple small peritoneal nodules

Question 49

MED12

Answer 49

leiomyomas, lieomyosarcomas

Question 50

peak incidence on lyeiomyosarcomas

Answer 50

before and after menopause, 40-60yo

Question 51

spread of lyeiomyosarcoma and MC met sites

Answer 51

hematogenously; lungs, bone, brain