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Repro II > Robbins Ch 22 - Lecture 2 > Flashcards

Robbins Ch 22 - Lecture 2 Flashcards

1
Q

shedding of the functionalis

A

menses

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2
Q

straight tubular glands line with regular, tall pseudostratified columnar cells w/ no evidence of mucus secretion or vacuolation

A

proliferative phase

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3
Q

appearance of secretory vacuoles beneath the nuclei in the gladular epi

A

postovulation

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4
Q

spiral arterioles, increase in ground substance and edema btwn stromal cells

A

late secretory phase

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5
Q

predecidual change occurs in the

A

late secretory phase

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6
Q

drives the prolideration of both glands and strom

A

estrogen

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7
Q

down-regulates expression of estrogen receptor in glands and stroma

A

progesterone

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8
Q

causes differentiation of the glands and function changes in stromal cells

A

progesterone

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9
Q

most frequent cause of dysfunctional uterine bleeding

A

anovulation

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10
Q

stromal condensation, eosinophilic epithelial metaplasia w/out glandular secretory changes and stromal pre-decicualization

A

anovulation

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11
Q

infertility ass’d with increased bleeding or amenorrhea d/t inadequate progesterone production during post-ovulatory period

A

inadequate luteal phase

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12
Q

acute endometritis is caused by

A

GAS, staphlyococci or another bacteria post delivery or miscarriage

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13
Q

ectopic endometrial tisse at a site outside of the uterus

A

endometriosis

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14
Q

5 MC sites of endometriosis

A

ovaries> uterine ligaments > rectovaginal septum > cul de sac > pelvic peritoneum

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15
Q

MC age group of endometriosis

A

active reproductive age - 3rd/4th decade

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16
Q

endometric implants in endometreosis show

A

release of proinflammatory factors, increased estrogen production by stromal cells

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17
Q

genetic changes in endmetriosis indicating possible clear cell ovarian cancer

A

PTEN, ARID1A

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18
Q

chocolate cysts

A

endometriosis that has cause fibrosis of the ovaries

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19
Q

presence of endometiral tissues within the uertine wall

A

adenomyosis

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20
Q

endometrial polyps have been ass’d with

A

tamoxifen

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21
Q

important cause of abnormal bleeding and frequent precursor to MC type of endometrial carcinoma

A

endometrial hyperplasia

22
Q

inactivation of PTEN tumor suppressor in common genetic alteration in

A

endometrial hyperplasia and carcinoma

23
Q

ass’ with prolonged estrogenic stimulation of the endometrium

A

endometrial hyperplasia

24
Q

WHO classifications of endometrial hyperplasia

A

non-atypical and atypical hyperplasia

25
Q

most common mutation acts to increase signaling though the PI3K/AKT pathway

A

hallmark of type 1 endometeroid carcinoma

26
Q

clinical settings of type 1 endometrial carcinoma (4)

A

unopposed estrogen, obesity, HTN, DM

27
Q

DNA mismatch repair gene defects

A

endometrial carcinomas in women with fam hx of HNPCC

28
Q

well differentiated tumors may be distinguised from hyperplasias by

A

lack of intervening stroma

29
Q

carcinoma that is confined to the corpus uteri

A

stage I

30
Q

carcinoma that involves the corpus and cervix

A

stage II

31
Q

carcinoma that extends outside the uterus but not outside the true pelvis

A

stage III

32
Q

carcinoma that extends outside the true pelvis or involved the mucosa of the bladder and rectum

A

stage IV

33
Q

usually arise in the setting of endometrial atrophy

A

type II endometrial carcinoma

34
Q

most common subtype of type II endometrial carcinoma

A

serous carcinoma

35
Q

most prevalent mutation in type II endometrial carcinomas

A

TP53

36
Q

PI3K and PP2A mutations are also common in

A

type II endometrial carcinoma

37
Q

precursor liesion of type II endometrial carcinoma

A

serous endometrial intraepithelial carcinoma

38
Q

peak incidence of endometrial carcinomas

A

postmenopausal F, 55-65yo

39
Q

endometrial adenocarcinomas with a malignant mesenchymal component

A

malignant mixed mullerian tumors

40
Q

MMMT mets usually only contain

A

epithelial components

41
Q

bulky polypoid mass that may protude out of the cervical os composed of both malignant epi and stromal components

A

MMMT

42
Q

large, broad-based endometrial polypoid growth with malignant-appearing stroma coexisting with benign, abnormally shaped endometrial glands

A

adenosarcoma of the endometrium

43
Q

estrogen-sensitive and responds to oophorectomy

A

adenosarcoma of the endometrium

44
Q

JAZF1 SUZ12 translocation

A

low-grade endometrial stromal sarcoma

45
Q

12q14 and p6 rearrangements

A

uterine lieomyoma

46
Q

well differentiated, regular, spindle-shaped smooth mm cells ass’d with hyalinization

A

leiomyoma

47
Q

rare variant leiomyoma that extends into vessels and can spread to other sites - MCly the lung

A

benign metastasizing leiomyoma

48
Q

dissmeniated peritoneal leiomyomatosis presents as

A

multiple small peritoneal nodules

49
Q

MED12

A

leiomyomas, lieomyosarcomas

50
Q

peak incidence on lyeiomyosarcomas

A

before and after menopause, 40-60yo

51
Q

spread of lyeiomyosarcoma and MC met sites

A

hematogenously; lungs, bone, brain

Repro II (12 decks)

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