Fitz - Antenatal & Perinatal Pharm Flashcards
(41 cards)
Used to promote lung maturation in pre-term delivery
Corticosteroids
Surfactant deficiency in pre-term infants (before 32 wks) leads to
RDS
Women btwn 24-34 wks gestation with threatened preterm labor, antepartum hemorrhage, preterm rupture of membranes, and conditions needing c-section( pre-eclampsia, HELLP) require
Antenatl corticosteroid
Antenatal corticosteroids used in pre-term delivery
Betamethasone, dexamethasone
Want to use corticosteroids that have higher activity at
Glucocorticoid receptors, not mineralicorticoid
Betamethasone and dexamethasone downstream effects in pre-term infants
Transcription of surfactant proteins by type 2 pneumocytes
CI’s antenatal corticosteroid tx
Mom with systemic infection, TB
Enzyme present in placenta that decreases efficacy of cortisol
11beta-HSD-2, cortisol > cortisone = not as active at GCRs!
Stimulus for oxytocin release from maternal post pit
Uterine stretch nerve impuse
Released from placenta to drive uterine contractions
PGF-2alpha
PG analogues that facilitate cervical ripening and uterine contrations
Dinoprostone, misoprostol
PG analogue that is more utero-selective
Dinoprostone
PG analogue that is a vaginal or cervical gel
Dinoprostone
Favored pharm agent for inducing labor
Oxytocin
Other use for oxytocin (not to induce labor)
Fetal stress tests
Drugs used to stop uterine contraction and prevent neonatal risk ass’d with prematurity
Tocolytic agents
MCly use tocolytic agent
MgSO4
MgSO4 helps protect mom against
Seizures ass’d with pre-eclampsia and HELLP synd
Drugs that relax uterine smooth m (5)
- beta 2 RAs
- Ca2+ ch antagonists
- MgSO4
- COX inhibitors
- oxytocin receptor antagonists
MCly used NSAIDs used
Infomethacin, ibuprofen
Oxytocin receptor antagonists
Atosiban
Ca cannel blocker used to dec uterine contractions
Nifedipine
Beta2 receptor agonists to induce uterine relaxation
Ritodrine, salbutamol, terbutaline
Competeive antagonist at Ca2+ channels
MgSO4
