SEDATIVE-HYPNOTIC DRUGS Flashcards
A barbiturate that is excreted unexchanged
Phenobarbital
What is the duration category of Thiopental?
Short acting
What is the duration category of Pento,Seco, Amobarbital?
Intermediate acting
A barbital that mediates migraines
Butalbital
A BZD that is known for its rapid tolerance
Triazolam
What is the only available administration of Flumazenil?
IV
What category in pregnancy safety is NEWER HYPNOTIC AND MELATONIN AGONIST?
Class C
What category in pregnancy safety is BARBITURATES?
Class D
What category in pregnancy safety is BZD?
Class D, Class X
What category in pregnancy safety is Busiperone?
Class B
In BZD, effected in panic disorder
Alprazolam
Where do BZD adheres in GABAa?
a and y subunit
affinity to MT1 and MT2 subtype melatonin receptors
Ramelteon
the hepatic enzyme majorly responsible for Ramelteon
CYP 1A2
Fluvoxamine is
an antidepressant that increases Ramelteon to 50 folds.
The active metabolite of Chlordiazepoxide, diazepam, prazepam, and clorazepate
Desmethyldiazepam (>40 half-life, BZD)
addition of triazole ring to?
1,2 position
triazolam and alprazolam is a?, has a on its structure?
Benzodiazepines, 1,2 triazole ring
metabolized to N-oxide derivative and desmethyleszopiclone?
Eszopiclone
What is the ramelteon antagonist?
Fluvoxamine
It’s metabolite is 1-2 pyrimidyl-piperazine (adrenoreceptor blocking action)
Busiperone
S-enantiomer of zopiclone
also metabolized to N-oxide derivative and desmethyleszopiclone
Eszopiclone
What is the antagonist of Benzodiazepine?
Flumazenil
