PHASE 1 REACTIONS

Question 1

What are the P450-dependent oxidations?

Answer 1

• Aromatic hydroxylations
• Aliphatic hydroxylations
• Epoxidation
• Oxidative dealkylation
• N-oxidation
• S-oxidation
• Deamination
• Desulfuration
• Dechlorination

Question 2

Amobarbital, pentobarbital, secobarbital, chlorpropamide, glutethimide, ibuprofen, meprobamate, phenylbutazone, digitoxin

Answer 2

Aliphatic hydroxylation

Question 3

Acetanilide, amphetamine, propanolol, phenobarbital, phenytoin, phenylbutazone, warfarin, naphthalene, benzpyrene

Answer 3

Aromatic hydroxylation

Question 4

Aldrin

Answer 4

Epoxidation

Question 5

Morphine, ethylmorphine, caffeine, benzphetamine, aminopyrine, theophylline

Answer 5

N- dealkylation

Question 6

Codeine, p-nitroanisole

Answer 6

O - dealkylation

Question 7

6-methylthiopurine, methitural

Answer 7

S- dealkylation

Question 8

Aniline, chlorphentermine

Answer 8

Primary amines

Question 9

2-Acetylaminoflourene, acetaminophen

Answer 9

Secondary amines

Question 10

Nicotine, methaqualone

Answer 10

Tertiary amines

Question 11

Thioridazine, cimetidine, chlorpormazine

Answer 11

S- oxidation

Question 12

Amphetamine, diazepam

Answer 12

Deamination

Question 13

Thiopental, parathion

Answer 13

Desulfuration

Question 14

Carbon tetrachloride

Answer 14

Dechlorination

Question 15

What are the P450-independent oxidation?

Answer 15

• flavin monooxygenase
• hydrolyses
• reductions

Question 16

Chlorpromazine, Amitriptyline, methimazole, benzphetamine, nortriptyline, desipramine, propylthiouracil

Answer 16

Flavin monooxygenase

Question 17

Aspirin, succinylcholine, procaine, clofibrate, methylphenidate

Answer 17

Esters

Question 18

Procainamide, lidocaine, indomethacin

Answer 18

Amide

Question 19

Metyrapone, methadone, naloxone

Answer 19

Carbonyl reductions

Question 20

Prontosil, tartrazine

Answer 20

Azo reductions

Question 21

Nitrobenzene, chloramphenicol, clonazepam, dantrolene

Answer 21

Nitro reductions