SAS 6 Flashcards
is a PGE1 that is naturally produced in tissues *used for ductus arteriosus in fetus
Alprostadil
is a PGE1 derivative that is used primarily for constipation cases
*also used in IBS
Lubiprostone
is methyl analog of PGE1 that creates barrier in GI but is also used with NSAIDS to prevent GI problems
Misoprostol
BimatoPROST, LatanoPROST, TafluPROST, travaPROST is a?
an analog of PGD F2a
Epoprostenol is a?
naturally occurring prostacyclin
Iloprost and treprotenil is a?
synthethic analog of prostacyclin
What are the non-selective NSAIDs? (5)
Indomethacin, Aspirin, Sulindac, Meclofenamate, Ibuprofen
What are the selective COX-2 inhibitors? (8)
Celecoxib, Meloxicam, Etodolac, Valdecoxib, Rofecoxib, Lumiracoxib, Etoricoxib, Diclofenac
/ anti-platelet effect that last 8-10 days and 6-12 hours in tissues that replaces COX enzyme
Aspirin
relatively equal to aspirin but LACKS INFLAMMATORY PROPERTY
Acetaminophen
an NSAIDs promoted systemically and is used for short-term
Ketorolac
an NSAIDS that inhibits re-uptake of NET and 5-HT
Tramadol
preferentially inhibits COX 2
Meloxicam
How long will it take for DMARDS to take effect?
2w. - 6 months
it inhibits Thymidylate synthase and AICAR Transformylase
Methotrexate
what is the effect of Methotrexate?
inhibition of cytokine production and biosynthesis of purine nucleotide
this lessens methotrexate adverse effect?
Leucovorin
a tetracycline antibiotic that is considered DMARDS
Minocycline
it’s active metabolites are 5-aminosalicylate-inflammatory bowel disease & Sulfapyridine RA
Sulfasalazine
use as a bridge until DMARDS take effect
Glucocorticoid
What are the IL-1 inhibitors?
Rilonacept, Anakinra, Canakinumab
T-cell depleting
Abatacept
IL-6 inhibitor
Tocilizumab
URIC ACID: retrieved from autumn crocus and cholchicum autumnale
Colchicine
