Section 15 Flashcards

1
Q

most important factor contributing to patient mortality in TCA toxicity

A

Cyclic antidepressant–induced cardiotoxicity

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2
Q

most frequent dysrhythmia noted in cyclic antidepressant toxicity; bupropion; SNRI; MAOI

A

Sinus tachycardia

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3
Q

most common symptom reported after cyclic antidepressant exposure

A

Altered mental status

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4
Q

most potent sodium channel blocker among the cyclic antidepressants

A

desipramine

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5
Q

most frequently reported cardiovascular abnormality in trazodone

A

Orthostatic hypotension

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6
Q

most common ECG abnormality in trazodone

A

moderate prolongation of the QT interval

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7
Q

Most common form of pharmacotherapy for depression

A

SSRIs

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8
Q

associated with the highest incidence of seizures among the SSRIs.

A

Citalopram

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9
Q

most serious drug-related adverse effect of SSRI psychopharmacotherapy

A

Serotonin syndrome

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10
Q

drug class most commonly associated with serotonin syndrome.

A

antidepressant

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11
Q

most common cause of death in serotonin syndrome

A

severe hyperthermia

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12
Q

Most common cardiovascular manifestations of antipsychotic overdose

A

tachycardia and orthostatis hypotension

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13
Q

antipsychotics with highest rate of QT prolongation

A

amisulpride and thioridazine

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14
Q

antipsychotics with highest development of type 2 diabetes mellitus and diabetic ketoacidosis

A

olanzapine

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15
Q

most common disorder creating diagnostic confusion is serotonin syndrome

A

NMS

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16
Q

most prevalent endocrine dysfunction of chronic lithium therapy

A

hypothyroidism

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17
Q

most common class of antiepileptic drugs used in developing countries

A

Barbiturates

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18
Q

most common alcohols ingested

A

Ethanol and isopropanol

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19
Q

most frequently used and abused drug in the world.

A

Ethanol

20
Q

Most frequently cited causes of death of MDMA

A

hyperthermia and hyponatremia

21
Q

the most common cause of an osmolar gap on serum electrolyte analysis

A

Ethanol ingestion

22
Q

most commonly sold as raw cactus or “buttons,”

A

peyote

23
Q

most common agent currently reported in NSAID overdoses

A

ibuprofen

24
Q

most common in acute overdose in methylxanthine toxicity

A

Hypokalemia

25
Q

most common cardiac manifestation of both caffeine and theophylline use and toxicity

A

sinus tachycardia

26
Q

most common effects of nicotine overuse

A

nausea and vomiting

27
Q

earlies manifestation of Acute digoxin toxicity

A

Nausea, vomiting, anorexia, and vague abdominal pain

28
Q

Most common arrhythmias in digoxin toxicity

A

premature ventricular contractions and bradycardic rhythms

29
Q

hallmark of severe toxicity in beta blockers

A

bradycardia with shock

30
Q

most common physiologic abnormality after overdose of CCB

A

Hypotension

31
Q

most serious clinical manifestation in overdose in Spironolactone and Eplerenone

A

Hyperkalemia and hypotension

32
Q

most typical adverse effect observed usually within 30 to 90 minutes after ingestion in doxazosin, prazosin, and terazosin (a1 adrenergic antagonist)

A

Orthostatic hypotension

33
Q

most commonly used α2-adrenergic agonist; primary indication for rebound hypertension

A

Clonidine

34
Q

most consequential adverse effect associated with ACEIs and ARBs

A

angioedema

35
Q

most frequent sign of acute valproic toxicity

A

CNS depression

36
Q

clinical sign most consistently associated with acute iron toxicity

A

vomiting

37
Q

most important factor guiding the decision to terminate deferoxamine therapy because measured iron levels are artificially depressed by the presence of deferoxamine and urine color change can be unreliable

A

clinical recovery of patient

38
Q

Most common radiologic finding in hydrocarbon pulmonary toxicity

A

bilateral infiltrates at the bases more common to be multilobar and to the right

39
Q

Most worrisome acute complication found in solvent abusers (hydrocarbons) is

A

sudden sniffing death syndrome

40
Q

Most common household alkali

A

bleach

41
Q

most common overdose that produces anticholinergic toxicity.

A

Antihistamine (particularly diphenhydramine) overdose

42
Q

most clinically significant cases of human metal poisoning

A

Lead and mercury

43
Q

most clinically significant toxic metalloid

A

Arsenic

44
Q

most common causes of death in arsenic poisoning

A

Hypotension and dysrhythmias

45
Q

most active form of vitamin D

A

d-α-tocopherol

46
Q

Most common adverse reaction to macrolide

A

Gi distress

47
Q

local anesthetic most commonly associated with methemoglobinemia

A

Benzocaine