Schizophrenia-UofT

Question 1

length of tx before symptoms start improving?

Answer 1

4-6 weeks

Question 2

How long should pts. stay on anti-psychotic therapy?

Answer 2

-atleast 18 months post-remission
-2-5 yrs/life-long if there’s multiple remission

Question 3

CYP interaction for each drug agent:
-Risperidone
-Olanzapine
-Ziprasidone
-Clozapine

Answer 3

-R: CYP2D6
-O:smoking
-Z: CYP3A4
-C: CYP 1A2 (*CIPRO)

Question 4

exhibits a high risk of aspiration pneumonia in elderly?

Answer 4

Quetiapine

Question 5

Unique side effects of each agent:
-Aripiprazole
-Clozapine
-Risperidone
-Lurasidone
-Ziprasidone
-Haloperidol
-1st gen anti-psychotics?

Answer 5

-A: Dose-related akathisia (inability to remain still)
-C: should be titrated up slowly due to the risk of intestinal obstruction
-R: Highest risk of prolactinemia
-O: Weight gain
-Q:Aspiration pneumonia
-L: Weight gain
-H: EPS side effect
______
-perphenazine: tardive dyskinesia

Question 6

Agents that must be taken with food?

Answer 6

-Lurasidone
-Ziprasidone

Question 7

SIG for asenapine ?

Answer 7

should be placed under the tongue & pt. is instructed NOT to eat or drink for a minimum of 10mins after administration

Question 8

(def): a state of abnormal muscle tone resulting in muscular spasm and abnormal posture

Answer 8

Acute dystonia

Question 9

(def): restlessness; pacing back and forth

Answer 9

Akathisia

Question 10

(def): causes stiff, jerky movements that you can’t control.

Answer 10

Tardive dyskinesia