Dyslipidemia

Question 1

Target levels of LDL, non-HDL, Apo-B?

Answer 1

LDL < 1.8 mmol/L
ApoB < 0.70 g/L
Non-HDL < 2.4 mmol/L

Question 2

When should fenofibrate be initiated for elevated triglycerides?

Answer 2

Not all patients with elevated triglycerides require fenofibrate initially. Patients with a triglyceride level greater than 10 mmol/L may be started on fenofibrate to avoid the risk of complications secondary to hypertriglyceridemia.

Question 3

Target levels of:
-waist circumference
-Triglyceride
-Systolic blood pressure
-Diastolic blood pressure
-Fasting glucose

Answer 3

a.Waist circumference: >102 cm in men and >88 cm in women
b.Triglycerides: ≥1.7 mmol/L
HDL cholesterol (HDL-c) <1.0 mmol/L in men an <1.3 mmol/L in women
c.Systolic blood pressure ≥130 mmHg
d. diastolic blood pressure ≥85
e.Fasting glucose ≥5.6

Question 4

progression of myopathy?

Answer 4

-Myopathy
-Myalgia
-Myositis
-Rhabdomyolysis

Question 5

when is the framingham risk score doubled? (multiplied by 2)

Answer 5

30-59 yrs without diabetes who have a positive family history.

Question 6

who should be screened for dyslipidemia?

Answer 6

men and women greater than or equal to 40.

• screen earlier if they are south asian or First Nation

Question 7

LDL levels where therapy is indicated:

Answer 7

high-risk: immediately
intermediate: greater than or equal to 3.5mmol/L
low-risk: greater than or equal to 5.0 mmol/L

Question 8

statin-indicated case?

Answer 8

• clinical atherosclerosis
• abdominal aortic aneurysm
  -Diabetes Mellitus
  -Chronic kidney disease
  -Familial hypercholesteremia
  -LDL-C ≥5 mmoL/L or ApoB ≥1.45 g/L or non-HDL-C ≥5.8 mmol/L

Question 9

-patients that have a triglyceride level greater than ____ should be started on fenofibrate.

Answer 9

> 10mmol/L

Question 10

In diabetes, at what LDL level should an add-on therapy be considered?

Answer 10

greater than or equal to 2 mmol/L

Question 11

In CVD, at what LDL level should an add-on therapy be considered?

Answer 11

greater than or equal to 1.8 mmol/L

Question 12

In hypercholestermia, at what LDL level should an add-on therapy be considered?

Answer 12

greater than or equal to 2.5mmol/L

Question 13

In hypercholestermia, at what LDL level should intermediate risk patients start therapy?

Answer 13

greater than or equal to 3.5mmol/L

Question 14

In hypercholestermia, at what LDL level should low risk patients start therapy?

Answer 14

greater than or equal to 5.00 mmol/L

Question 15

At what BMI should patients be screened for dyslipidemia?

Answer 15

greater than or equal to 30.

Question 16

In chronic kidney disease, at what LDL level should an add-on therapy be considered?

Answer 16

greater than or equal to 2.0 mmol/L

Question 17

At what age should patients start getting screened for dyslipidemia?

Answer 17

-older than or equal to 40 years old in both men & women
-(or post-menopausal)