Schizophrenia Flashcards
Define schizophrenia
A severe mental illness in which contact with reality and insight are impaired.
What is the DSM?
Diagnostic and Statistical Manual
5th version
Mainly used in the US
What is the ICD?
International Classification of Diseases
11th version
Mainly used in UK and Europe
What are Positive symptoms?
Additional symptoms that interfere with reality. They are in addition to their normal experiences.
What are Negative symptoms?
The loss of abilities
Who is most common to get schizophrenia?
Men who live in a city with a low socio-economic status
What are the positive symptoms in the classification for schizophrenia?
Delusions: unshakable belief in something that is very unlikely, bizarre or obviously untrue.
Disorganised Speech: often known as a ‘word salad’ where an individual speaks in ways that are completely incomprehensible.
Hallucinations: bizarre and unreal perceptions of the environment. These can be auditory, visual, olfactory, or tactile.
What are the negative symptoms in the classification of schizophrenia?
Speech Poverty: alogia, where speech becomes lessened. It may be difficult to produce words or coherent sentences.
Affective Flattening: a lack of emotions where the persons voice becomes dull and monotonous and their face takes a constant blank appearance.
Catatonic or Disorganised Behaviour: individual behaves in ways that seem inappropriate or strange to the norms of society e.g. lack of motivation.
Avolition: apathy, where they have a lack of motivation to follow through plans and neglect household chores.
Anhedonia: inability to enjoy things that they used to enjoy, food (physical anhedonia) or social withdrawal (social anhedonia).
What is diagnostic reliability?
Means that a diagnosis of schizophrenia must be repeatable.
Clinicians must be able to reach the same conclusions at 2 different points in time.
What is IRR?
Inter-rater reliability
Measured by a statistic called a Kappa score
1- indicates perfect inter-rater agreement
0- indicates zero agreement
0.7 or above is considered good.
What is gender bias?
Said to occur when accuracy of diagnosis is dependent on the gender of an individual, effects accuracy.
Is there any symptom overlap with schizophrenia?
Bipolar disorder also involves positive symptoms like delusions and negative symptoms like avolition.
What is comorbidity, and outline the research?
When 2 or more conditions are happening at the same time.
Buckley et al. found that comorbid depression occurred in 50% of his patients
Kessler argues that comorbid depression is a common cause for suicidal behaviour in SZ individuals.
Evaluate the classification of SZ
+ Buckley found co-morbidity rates with SZ, depression 50%, drug abuse 47%
- 153 patients diagnosed by multiple doctors had only a 54% concordance rate between Drs assessments, Low IRR
What 4 things make up the biological explanation of schizophrenia?
Family studies
Adoption studies
Twin studies
Candidate genes
Describe family studies as a biological explanation
Schizophrenia is more common among biological relatives, and the closer the degree of relative the higher the risk.
Gottesman and Shields: children with 2 SZ parents has a concordance rate of 46%. Children with 1 SZ parent had a concordance rate of 13%.
Siblings were 9%
Cousin, uncle, aunt were 2%
Nephew, niece were 4%
Grandchild 5%
Ferternal twins 17%
Identical twins 48%
Describe adoption studies as a biological explanation
Tienari et al. (Finland) found 164 adoptees whose bio mothers had been diagnosed with schizophrenia, 11 also were diagnosed with SZ.
Compared to just 4/197 control adoptees.
Clearly a genetic component
Describe twin studies as a biological explanation
Gottesman and Shields found concordance rate monozygotic=48%
dizygotic=17%
Therefore SZ is inherited through genes
Describe candidate genes as a biological explanation
SZ is polygenic
Ripke looked at date of genome wide studies:
37,000 with SZ compared to 133,000 controls
The are 108 different genetic variations to have an increased risk of SZ
SZ is aetiologically hetrogenous.
Evaluate the genetic factors
- Concordance rates from both family studies can be explained by factors other than genetics: could be down to external factors, childhood, diet?
- Twin studies for SZ have very small sample sizes, so we cannot generalise to the whole population.
- Many of these studies are dated, there has since been changes in the diagnostic criteria so therefore may not be relevant to now.
What is the role of dopamine neurons?
Instrumental in regulating attention, active in the limbic system (an area of the brain governing emotion) .
If disturbed may lead to problems with attention, perception and thought.
Outline the original dopamine hypothesis
-Messages from neurons that transmit dopamine fire is too easily or too often leading to symptoms of SZ.
-Schizophrenics are thought to have abnormally high numbers of D2 receptors on recieving neurons resulting in more dopamine binding therefore more neurons firing.
What are Amphetamines in the original dopamine hypothesis?
a dopamine agonist, stimulates nerve cells to be flooded - large doses can cause hallucinations and delusions.