Schizophrenia Flashcards
What percentage and type of people in the population does Sz affect? (age, gender, background…)
- 1% population
- Working class, urban areas
- Late teens/early 20s/30s
- Similar male/female rates but more men diagnosed
What are the positive and negative symptoms of Sz?
+ Hallucinations
+ Delusions
- Avolition
- Speech poverty
others: allogia (jumbled speech)
+ = excess - = defecit behaviours
What is the name of the 2 ways to classify Sz? What is needed to classify Sz in these ways?
ICD 10 and DSM 5
ICD 10 - 1 positive or 2 negative symptoms
DSM 5 - 2 sypmtoms - at least 1 positive - present for at least 6 months
What are the inter-reliabiltiy rates for ICD and DSM?
ICD = 60%
DSM = 81%
What are the 3 subtypes in the ICD classification?
PARANOID - delusions, hallucinations, speech poverty, extreme interest in coincidences - treatment works well.
DISORGANISED - unpredicatable, allogia, absense of emotion, shallow/inappropriate mood, thought distrubance
CATATONIC - catatonic trance (won’t move), hyperactivity, vivid hallucinations, motiveless obedience/disobedience
What are the symptoms to classify Sz using DSM?
- Delusions
- Hallucinations
- Disorganised speech (allogia)
- Abnormal psychomotor behaviour (e.g. tardive dyskinesia)
- Negative symptoms
What are the factors that affect validity of diagnosis?
Comorbidity, Symptoms overlap, Gender bias, Cultural bias
What is comorbidity? Give some examples to do with Sz. What is the issue with this?
When disorders occur together = e.g. 50% depression, 29% PTSD, 23% OCD
Seperate disorders?
Give an example of symptoms overlap for Sz. What is the issue with this?
Bipolar disorder also has hallucinations, delusions and avolition.
Can lead to misdiagnosis.
Give an example of symptoms overlap for Sz. What is the issue with this?
Bipolar disorder also has hallucinations, delusions and avolition.
Can lead to misdiagnosis.
Give an example of cultural bias with diagnosing Sz.
Afro-carribeans are 7x more likely to be diagnosied in Britain.
Genuine difference or cultural bias?
What are the 3 biological explanations for Sz?
Genetic theroy, Dopamine hypothesis and Englarged Ventricles
How many genetic variations are associated with Sz? What does this mean Sz can be described as?
What are the concordance rates for Sz with MZ and Dz twins and parents?
108 - polygenic
MZ twins = 50%
DZ twins = 15%
Parents = 5%
Evaluate the genetic theory (2+, 1-)
+ Supporting research - Genain Quadruplets - identical, all have Sz but different intensities - abusive father/trauma
+ Practical applications - treatment sooner - prevent illness
- Socially sensitive - stigma, pressure not to have children, hopelessness
Describe the dopamine hypothesis - what does dopamine affect? What causes + and - symptoms?
Dopamine affects Learning, Attention, Memory, Motivation, Movement, Anxiety and Sleep. (Lammmas)
- Dopamine - excitatory - + symptoms
- Reduced dopamine in Wernickle’s area and prefrontal cortex = - symptoms
- Dopamine levels could be affected by genes.