Schizophrenia Flashcards
what are the four key symptoms of schizophrenia
thought insertion, hallucinations, delusions, disorganised thinking
thought insertion
believing one’s thoughts have been implanted by an external source
hallucinations
perceptual experiences which do not correspond with reality
delusions
fixed beliefs that are resistant to change and implausible to people of the same cultural background
disordered thinking
jumbled and unrelated thoughts leading to incoherent speech
lifetime prevalence of schizophrenia
0.3-0.7%
how does lifetime prevalence vary
varies with ethnicity, nationality and geographic origin in immigrants
the onset of schizophrenia, males vs. females
earlier in males (early to mid-20s)
females (late-20s)
features of schizophrenia
minority may recover completely
but most experience chronic, episodic impairment and some show progressive deterioration, with increasingly brief periods of remission and severe cognitive deficits.
positive symptoms reduce over time but delibating negative symptoms often remain
strength of schizophrenia diagnosis
high degree of consistency with DSM-5 and ICD-10
hyperdopaminergia
excess dopamine
chlorpromazine and reserpine, helpful in alleviating the symptoms of schizophrenia
schizophrenic symptoms may be linked to high levels of dopamine
positive symptoms of dopamine
hypodopaminergia
dopamine deficiency
negative symptoms of schizophrenia derived from lack of dopaminergic activity
positive schizophrenic symptoms
delusions and hallucinations
from hyperdopaminergia
negative schizophrenic symptoms
flat effect and mutism
from hypodopamingeria
strength of neurotransmitters as an explanation
supported by research on rats treated with amphetamines.
rats given nine amphetamine injections. showed schizophrenia-like symptoms
weakness of neurotransmitters as an explanation
cannot explain social causations like second-generation immigrants
how is schizophrenia a heritable condition
estimate for the heritability of schizophrenia 79%
identify responsible. genes that are present in family members who have schizophrenia
gene mutations
schizophrenia can appear in the absence of a family history.
DNA code in genes may mutate
which will lead to schizophrenia
what are the two candidate genes that are linked to the presence of schizophrenia
COMT gene and DISC1 gene