SARS-CoV-2

Question 1

SARS-CoV-2 micro description

Answer 1

Enveloped, single stranded, positive sense virus with large genome

Question 2

SARS-CoV-2 micro description

Answer 2

Enveloped, single stranded, positive sense virus with large genome

Question 3

SARS-CoV-2 pathogenesis

Answer 3

Spike protein binds to ACE2 in the lungs → viral entry → inflammatory repsonse activated involving virus specific T cells
In severe cases, this can trigger a cytokine storm (IL-1, IL-6 and TNF-alpha) → widespread inflammation → ARDS

Question 4

SARS-CoV-2 treatment

Answer 4

Dexamethasone
Antivirals - Remdesivir (RNA polymerase inhibitor), Molnupiravir (RNA polymerase inhibitor), Paxlovid (targets protease)
Monoclonal antibodies - sotrovimab (spike protein), tocilizumab (IL-6 receptor)