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Crash > Sarcoma > Flashcards

Sarcoma Flashcards

1
Q

Types of sts

A

Translocation associated - young30-50

Complex karyotype- 50-60

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2
Q

TRANSLOCATION ASSOCIATED

SARCOMAS

A 
Myxoid/ Round cell Liposarcoma
Ewing's sarcoma
.
Synovial sarcoma
Desmoplastic small round cell tumour
Alveolar Rhabdomyosarcoma
Alveolar soft part sarcoma
DFSP 
Extraskeletal myxoid chondrosarcoma
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3
Q

Complex karyotype sts

A 
Well
Well differentiated and
Dedifferentiated
liposarcoma
Pleomorphicliposarcoma
Myxofibrosacoma
Undifferentiated Pleomorphic sarcoma
Leiomyosarcoma
MPNST
Angiosarcoma
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4
Q

What is the most common radiation induced sarcoma

A 
HISTOLOGY
Undifferentiated pleomorphic
sarcoma 26%
Angiosarcoma 21
Fibrosarcoma 12
LMS 12
MPNST 9
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5
Q 
4. What is the life time risk of MPNST in
Neurofibromatosis-I(17q 11.2)
a. 10%
b. 17%
c. 31%
d. 53%
A

10% of patients with neurofibromatosis are

thought to develop STS.

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6
Q

Most common histologic type in Li-Fraumeni

syndrome

A

RMS - 55%
Fibrosarcomas - 13%
• UPS - 10%.

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7
Q

Rb gene associated sts m/c

A

LMS

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8
Q

Chemical agents sts

A

Arsenic
Thorotrast
Vinyl chloride

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9
Q

Intermediate metastatic tumors

A 
DFSP
hemangiopericytoma
Kaposi
Myoepithelial ca
Inflammatory myofibroblastic tr
Infantile fibrosarcoma
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10
Q 
The prevalence
of pulmonary
metastases among
patients
previously
treated
for
extremity STS
approximately
A

19%

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11
Q

Ledderhose disease implies

A

Plantar fibromatosis

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12
Q

——% of FAP patients develop desmoid tumors.

A

20

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13
Q

Dfsp

Adjuvant rt useful when

A 
Cd34+
COL1A1
PDGFRB translocation
Mononuclear spindle cells 
Margin 2 cm or more
Art when vlose margins or rec disease
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14
Q

Bednar tumor

A

Melanin pigmented DFSP

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15
Q

RT IN DFSP

A

Radiation is useful in
a. Recurrent disease
Close or positive surgical margins.

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16
Q

Sts Ntrk inhibitor

A 
Characterized by ETV6-NTRK3 fusion
NTRK inhibitors such as larotrectinib.
Surgery is the primary modality.
Fibrosarcoma
Herring bone pattern
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17
Q

Vhich of the following is part of the FNCLCC

grading of soft tissue sarcoma?

A

a. Differentiation score
b. Necrosis score
C.
Mitotic score

18
Q

Regional lymph node involvement for STS is

uncommon (2% to 10%).

A 
Angiosarcoma
Rhabdomyosarcoma
• MFH,
•Epithelioid sarcoma
Clear cell sarcoma
• Liposarcoma.
CLEAR MFH
19
Q

Visceral sarcoma T stage

A 
1- organ confined
2- extend into tissue beyond organ 
A- serosa or viscer peritoneum 
B- beyond serosa
3- another organ
4- a multiple -2 
b- 3-5
c- >5 sites
20
Q

Drug used in inflammatory fibrobalstic tumor

A

a. Crizotinib
b. Imatinib
c. Rituximab

21
Q
  1. Doge- Potter syndrome occurs with
A

Patients present with a very large SOlitary Fibrous Tumor
and
hypoglycemia
(Doege-Potter
syndrome),
which is associated with production of a form
of IGF2 by these tumors.

22
Q

Mri features of liposarcoma

A

Adipose<75%
Thick septa>2mm
No adipose areas
Size>10Cm

23
Q
  1. Which type of liposarcoma is susceptible for

unusual sites of metastases?

A
  1. ALT/WDLS- supernumerary ring 12q14-15
  2. Dedifferentiated liposarcoma (DDLS)
  3. MYXOID ROUND CELL✅-40%-FUS DDIT3 transloaction in 90%
  4. Pleomorphic <5%
24
Q

Which are the places leiomyoma can arise?

A

Blood vessels
Skin
Uterus
Gastrointestinal tract.

25
Q

M/c sts in children

A

Rhabdomyosarcoma

26
Q

Types of rhabdomyosarcoma

A

Embryonal -VAC Regime
Alveolar- PAX3-FOXO1 fusion transloction
And pleomorphic- m/c form in adults

27
Q

What is true about extraskeletal

osteosarcoma?

A

> 50yrs

28
Q
  1. Which of the tumours are PEComas?
A

a. Lymphangioleiomyomatosis
b. Angiomyolipomas
c. Clear cell “sugar” tumors of the lung
a& b Associated with tuberous sclerosis

29
Q

Melanoma of soft parts

A

Clear cell sarcoma

30
Q

Brain imaging in sts done in

A

Alveolar soft part sarcoma,

Clear cell sarcoma, and angiosarcoma.

31
Q

Kawaguchi criteria

A 
Thick barriers-3 cm
lliotibial band
Presacral fascia
Joint capsule.
Periosteum of an infant or young child.
Thin- 2 cm
muscle fascia, adult periosteum, vessel sheath, epineurium
Growth plate :
Infant or young child - Thick barrier.
• Linear appearance -Thin barrier.
JOINT CARTILAGE- 5 cm
32
Q

Most common rp sarcoma

A

Liposarcoma 60%

Lms- 22%

33
Q

Indications for post-operative radiotherapy in sts

A

All high grade lesions
All recurent lesions
• Low grade lesions if deep seated /or 2 Scm/or margin+

34
Q

ClasicalTikhoff linberg resection

A

Type 4

Extra articular total scapulectomy and humeral head resection

35
Q

Removing part of sacrum which type of hemipelvectomy

A

Type 4
Type1- iliac crest
2- ischium
3- pubis

36
Q

Periosteal isteosarcoma m/c

A

Ant tibial shaft

37
Q

Paraosteal os

A

Distal femur

38
Q

Clear cell chondrosarcoma m\c site

A

Femora head

39
Q

Ewsr1-FLI1 fusion

A

22 -11

VAC REGIME

40
Q

Classification based on response to chemo in bone tr

A

Picci

Huvos

41
Q

Bone tr with epithelial component

A 
Adamantinoma
Diaphys
Tibia
Pan cytokeratin +
Soap bubble xray

Crash (20 decks)

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