Bladder Malignanccy Flashcards
which is involved in ca bladder Aristocholic acid N acetyl transferase Glutathiones transferase All of the above
All
Lynch syndrome life time risk of utuc
6%
Screen for lynch syndrome in utic if
Based on this association, it has been suggested
that patients with UTUC should be evaluated for
Lynch syndrome if they
(1) are younger than 60 years of age;
(2) have a family history of UTUC, colon cancer
diagnosed before age 60 years, or endometrial
carcinoma; or
(3) have a personal history of colon or
endometrial cancer
Decreased risk in women in ubca
Parity late menarche and ocp use
Painless gross hematuria at dx
85%
Noninvasice gold std
Cytology
Mc tcc
Bladder > renal pelvis. Ureter urethra
Urachus bladder dome which type
Adenoca than tcc
Premalignant lesions
The 2004 World Health Organization classification
system for urothelial neoplasia classifies pre-
malignant lesions as urothelial hyperplasia (flat
and papillary), reactive atypia, urothelial atypia
of unknown significance (AUS), urothelial
dysplasia, and low-grade intraurothelial neoplasic
Metaplasia is benign.
Mc stage in bladder
T1
Urinary conduit jejunum compli
Ileuma nd colon compli
Jejunum hypochloremic hyperkalemic metab acidosis
Ileum and colon- hyperchloremicb metab acidosis
Intravesical therapy rash and granulomatous prostatitis are side effects of
Mitomycin c and bcg respectively
Induction and maintenance therapy of bcg for
Induction 6 wks
Maintenance for intermediate - 1 yr
High - 3 yr
Bladder sparing feasible when?
tumor presentations associated with successful
bladder-sparing therapy include:
solitary T2 or early T3 tumors(typically <6 cm in
size),
no tumor-associated hydronephrosis,
tumors allowing a visibly complete TURBT,
invasive tumors not associated with extensive
carcinoma in situ, and
urothelial carcinoma histology
Immediate inteavesica therapy can be giben in
Low frade low volume Ta disease
Within 24 hrs of turbt
Gemcitabine > mitomycin
