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ENDOCRINE Flashcards

1
Q

Pnet men or women more common

A 
M>f
Median age -60
64% distant mets at presentation
14%local disease 22% regional disease
Men1
Tsc
Vhl exon 3 aggressive 
Nf1- somatostatinoma
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2
Q

Ghrelin from which cell

A

P/D1 cells

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3
Q

General Markers of NETs

A

Chromogranin
Synaptophysin
NSE
protein gene product 9.5( PGP)

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4
Q

Markers diff bw PNET &NET

A

NESP55a pnet and pheo

PDX1

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5
Q

Pnet main pathways

A

Men1
Daxx or atrx
Mtor

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6
Q

Whicbtumor acts like exocrine

A

Mixed nets

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7
Q

Grades of pnet

A

Mitotic count and ki67

G1-3

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8
Q

Nonfunctional or nonsecretory pnet

A

Pancreatic polypeptide- no clincial syndrome

Rarely diarhea dm ulcer

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9
Q

Drugs for pnet

A 
Sunitinib
Everolimus
Somatostatin analogues
Streptozocin based ct doxo fu capacetabine
Dacarbazine and temozolomide
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10
Q

Somatostatin analogues

A

Octreo lanreo- sstr 2 >sstr5

Pasireotide- ssrt1,2,3,5

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11
Q

Peptide receptir rt

A

Lu 177 dotao
In 111 dtoa
Y90 dota octreo

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12
Q

Mc functioning pnet

A

Insulinoma

Gastrinoma in duo

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13
Q

Secretin stimulation level and ca stimulation level in equivocal gastrin levels

A

Secretin -200

Ca-395

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14
Q

Gastrinoma in pancreas mc site

A

Head or uncinate

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15
Q

In MEN 1 with ZES which type of gastric

carcinoid occurs

A

Type 2

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16
Q

Insulinoma diagnostic level

A

> 3microIU insulin

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17
Q

Verner morrison syndrome

A

Vipoma
Watery diarrhoea
Hypokalemia
Achlorhydria

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18
Q

Necrolytic migratory erythema

A 
Glucagonoma
T/t oha and insulin
Nem -100%
Dm- 83%
Stomatitis and wt loss 67%
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19
Q

Von rechlingausen asso with net?

A

Somatostatinoma

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20
Q

Mc carcinoid

A

Gi> lung

SI>

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21
Q

Risk factors for midgut carcinoid

A

Age
Male sex
Increased bmi
Menopausal hrt

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22
Q

Carcinoid markers

A

Specific- 5hiaa

Chg A

23
Q

Which carcinoid produce acth

24
Q

Mc cause of ectopic ACTH syndrome

A

Bronchial carcinoid

25
100 %specific for midgut carcinoid
Ct enteroclysis
26
Which test identifies whether pt will | respond to therapy( lu 177) or not?
Ga 68 dotate
27
Mc site of esophageal carcinoid
Lower
28
Mc gastric net
Type 1>type 3 | Type 3- no hypergastrinemia and has high mets chance
29
Carcinoid symptom mc
Flushing 94% Diarrhoea 80% Heart disease 40% rt heart valvular
30
Increased cardiac disease of 5hiaa more than
100
31
3 non classical men2A
Men 2a with cutaneous lichen amyloidsosis, with hirschspring disease And familial MTC
32
Wagermann frobose
Men 2b or 3
33
Collagenomas and angiofibromas common in which men
1
34
Cdk1b mutation in which men
4 - kidney and reproductive organs
35
Mcc of death un men1
Pnet malignan | > thymic carcinoid
36
Inability to cry
Men 3
37
P27 protein product is seen in whcih men
Men 4
38
Cla men 2a codon
``` 634 in exon 11 609 611 618 620 in exon 10 in hirchsprung ```
39
Men1 genetic screening when
.2/> men1 related tumors Multiple abnormal pth gland before 30 yrs Recurrent hot at young age Gastrinoma and hot or multiple pnetd at any age Fho renal stones endocrine tumors
40
Phpt men1 surgery
3.5 gland removed + thymectomy
41
Basal acid output > ….. dx of ZES
15 mEq /hr
42
All cases surgery
Insulinoma
43
Codon in men2b
16 M918T | 15 A883F
44
Local adv ileal net treatment
Ileal resection + nodes+ cholecystectomy ( octreotide causes stone)
45
Ssr pet
68 ga dotatate 68ga dotatoc 64cu dotatate
46
Carcinoid appendix mgt | When is rt hemi needed
=2 cm - simple appendectomy | >2 or incomplete or positive node or margin— rt hemicolectomy
47
Nodes for appendectomy net in > 2 cm
12
48
Telotristat
Im carcinoid when its uncontrolled with lanreo and octreo to control diarrhoea
49
Pnet cam be observed if
Low grade less than 2 cm Incidental Non functional
50
Glucagonoma mc site
Tail
51
Mitotic rate per
10hpf or 2 mm squared
52
Typical and atypical carcinoid in bronchus
Bronchus Typical <2 mitosis Atypical 2-10 Small and large cell >10
53
Pancreatic net origin identified by
Isl 1 and PAX 8 Lung -TTF Bowel- CDX2
54
Glucagonoma syndrome
Diabetes Dermatitis Deep vein thrombosis Depression.

Crash (20 decks)

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