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Crash > ENDOCRINE > Flashcards

ENDOCRINE Flashcards

1
Q

Pnet men or women more common

A 
M>f
Median age -60
64% distant mets at presentation
14%local disease 22% regional disease
Men1
Tsc
Vhl exon 3 aggressive 
Nf1- somatostatinoma
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2
Q

Ghrelin from which cell

A

P/D1 cells

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3
Q

General Markers of NETs

A

Chromogranin
Synaptophysin
NSE
protein gene product 9.5( PGP)

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4
Q

Markers diff bw PNET &NET

A

NESP55a pnet and pheo

PDX1

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5
Q

Pnet main pathways

A

Men1
Daxx or atrx
Mtor

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6
Q

Whicbtumor acts like exocrine

A

Mixed nets

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7
Q

Grades of pnet

A

Mitotic count and ki67

G1-3

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8
Q

Nonfunctional or nonsecretory pnet

A

Pancreatic polypeptide- no clincial syndrome

Rarely diarhea dm ulcer

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9
Q

Drugs for pnet

A 
Sunitinib
Everolimus
Somatostatin analogues
Streptozocin based ct doxo fu capacetabine
Dacarbazine and temozolomide
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10
Q

Somatostatin analogues

A

Octreo lanreo- sstr 2 >sstr5

Pasireotide- ssrt1,2,3,5

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11
Q

Peptide receptir rt

A

Lu 177 dotao
In 111 dtoa
Y90 dota octreo

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12
Q

Mc functioning pnet

A

Insulinoma

Gastrinoma in duo

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13
Q

Secretin stimulation level and ca stimulation level in equivocal gastrin levels

A

Secretin -200

Ca-395

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14
Q

Gastrinoma in pancreas mc site

A

Head or uncinate

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15
Q

In MEN 1 with ZES which type of gastric

carcinoid occurs

A

Type 2

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16
Q

Insulinoma diagnostic level

A

> 3microIU insulin

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17
Q

Verner morrison syndrome

A

Vipoma
Watery diarrhoea
Hypokalemia
Achlorhydria

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18
Q

Necrolytic migratory erythema

A 
Glucagonoma
T/t oha and insulin
Nem -100%
Dm- 83%
Stomatitis and wt loss 67%
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19
Q

Von rechlingausen asso with net?

A

Somatostatinoma

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20
Q

Mc carcinoid

A

Gi> lung

SI>

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21
Q

Risk factors for midgut carcinoid

A

Age
Male sex
Increased bmi
Menopausal hrt

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22
Q

Carcinoid markers

A

Specific- 5hiaa

Chg A

23
Q

Which carcinoid produce acth

A

Thymic

24
Q

Mc cause of ectopic ACTH syndrome

A

Bronchial carcinoid

25
Q

100 %specific for midgut carcinoid

A

Ct enteroclysis

26
Q

Which test identifies whether pt will

respond to therapy( lu 177) or not?

A

Ga 68 dotate

27
Q

Mc site of esophageal carcinoid

A

Lower

28
Q

Mc gastric net

A

Type 1>type 3

Type 3- no hypergastrinemia and has high mets chance

29
Q

Carcinoid symptom mc

A

Flushing 94%
Diarrhoea 80%
Heart disease 40% rt heart valvular

30
Q

Increased cardiac disease of 5hiaa more than

A

100

31
Q

3 non classical men2A

A

Men 2a with cutaneous lichen amyloidsosis, with hirschspring disease
And familial MTC

32
Q

Wagermann frobose

A

Men 2b or 3

33
Q

Collagenomas and angiofibromas common in which men

A

1

34
Q

Cdk1b mutation in which men

A

4 - kidney and reproductive organs

35
Q

Mcc of death un men1

A

Pnet malignan

> thymic carcinoid

36
Q

Inability to cry

A

Men 3

37
Q

P27 protein product is seen in whcih men

A

Men 4

38
Q

Cla men 2a codon

A 
634 in exon 11
609
611
618
620 in exon 10 in hirchsprung
39
Q

Men1 genetic screening when

A

.2/> men1 related tumors
Multiple abnormal pth gland before 30 yrs
Recurrent hot at young age
Gastrinoma and hot or multiple pnetd at any age
Fho renal stones endocrine tumors

40
Q

Phpt men1 surgery

A

3.5 gland removed + thymectomy

41
Q

Basal acid output > ….. dx of ZES

A

15 mEq /hr

42
Q

All cases surgery

A

Insulinoma

43
Q

Codon in men2b

A

16 M918T

15 A883F

44
Q

Local adv ileal net treatment

A

Ileal resection + nodes+ cholecystectomy ( octreotide causes stone)

45
Q

Ssr pet

A

68 ga dotatate
68ga dotatoc
64cu dotatate

46
Q

Carcinoid appendix mgt

When is rt hemi needed

A

=2 cm - simple appendectomy

>2 or incomplete or positive node or margin— rt hemicolectomy

47
Q

Nodes for appendectomy net in > 2 cm

A

12

48
Q

Telotristat

A

Im carcinoid when its uncontrolled with lanreo and octreo to control diarrhoea

49
Q

Pnet cam be observed if

A

Low grade
less than 2 cm
Incidental
Non functional

50
Q

Glucagonoma mc site

A

Tail

51
Q

Mitotic rate per

A

10hpf or 2 mm squared

52
Q

Typical and atypical carcinoid in bronchus

A

Bronchus
Typical <2 mitosis
Atypical 2-10
Small and large cell >10

53
Q

Pancreatic net origin identified by

A

Isl 1 and PAX 8
Lung -TTF
Bowel- CDX2

54
Q

Glucagonoma syndrome

A

Diabetes
Dermatitis
Deep vein thrombosis
Depression.

Crash (20 decks)

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