Parathyroid Flashcards
1
Q
M/c PTH
A
Adenoma- 85%
Involving 4 glands- 10%
Double - 2-5
Ptc-<1
2
Q
Syndromes
A
Men 1
2a
Hpt jt
Familial
3
Q
Bone manifestations
A
© Bone manifestations are © Osteitis fibrosa cystica © Bone resorption © Salt and pepper skull © Fractures
4
Q
How many cancers non secretory Pnet
A
<10%
5
Q
Ln mets in ca in pth
A
15-30%
Palpable neck swelling 40%
6
Q
Most common cause of death in pth
A
Uncontrolled hyper ca
7
Q
Adenoma vs carcinoma in net
A
Locoregional invasion
Distant Mets
8
Q
Ca vs benign
Molecular
A
Ki67+
Galectin 3+
Parafibromin neg
9
Q
Ajcc tnm pth
A
Tis- atypical prh neoplasm
1- localised to gland with limited extension to soft tissue
2- direct inv into thy gland
3- inv to RLN esoph trach skelet muscle Ln thymus
4- major BV or spine
10
Q
Atypical pth neoplasm
A
Less tumor necrosis than ca
11
Q
Metastatic disease path treatment
A
Cinacalcet 30mg bd Casr modulated Denosumab can be used if refractory Glucocorticoids also can be used
