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Crash > Gynec Onco > Flashcards

Gynec Onco Flashcards

1
Q

Mc symptoms in ca cervix

A

Bleeding

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2
Q

Ca cervix eith hydroneph

A

3B

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3
Q

Ca cervix with prametrial inv

A

2 b

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4
Q

Lesion inv upper third epithelium

A

Cin 3

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5
Q

Mc abn Pap test result

A

Ascus 2-9%

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6
Q

Ascus best mgt

A

Hpv dna test

Alts trial

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7
Q

Adenoca instiu cin express ihc? Tsg?

A

P16 30-60%

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8
Q

Fertility sparing sx not done when

A

Gastric type adenoca
Small cell neuroendocrine
Adenoma malignum

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9
Q

Fertility sparing prefered for

A

Less than 2 cm

Upto 1B2

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10
Q

How much neg margin cone excision in fertility sparing

A

3 mm

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11
Q

Preferred method of cone biopsy in malignancy

A

Cold knife conization

Leep in hsil

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12
Q

Treatment for 1B3

A

Chemorad

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13
Q

2A1

A

Surgery

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14
Q

Modified rad hysterectomy

A

1a1 with lvi

and 1a2

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15
Q

Microinvasive ca

A

Less tha 5 mm depth

Largest extension les than 7mm

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16
Q 
• When to do revision surgery after incidental
finding in simple hysterectomy
sAwithvs
@ l3 with negative margins
© 3 with positive margins
a Gross residual disease
A

None

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17
Q

Sedlis criteria

A 
Lvsi
Strimal invasion
Tr size
Criteria for extrenal pevic rad after radical hysterectomy in 
Node neg
Margin neg
Parametria neg
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18
Q

Adenoma malignum aw which syndrome

A

Peutz jeghers

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19
Q

Ca cervix figo

Pelvic ln + is

A

3C

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20
Q

Figo staging

A

Read

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21
Q

Lnd which stage onwards in ca cervix

A

Ia1 eith lvi or 1a2

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22
Q

Hsil treatment

A

Leep

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23
Q

Cin 2 is div into lsil and hsil based on

A

P16

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24
Q

Infants squamocolumnar junction at mcly in cervix

A

Ectocervix

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25
Q

Nueroendocarcinoma of cevix most sensitive marker

Most specific

A

Sensitive CD56 Synaptophysin

Specific Chromogranin

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26
Q

Colposcopy

Sharp border inner border sohn ridge sign seen in

A

Grade 2 major

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27
Q

Staging of ca cervix

Pet ct or pet mri in

A

Nore than or eq 1B1

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28
Q

Reid index

A

Marhin
Colour
Vessels
Iodine staining

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29
Q

Swede index

A 
Aceto uptake
Margins or surface
Vessels
Lesion size
Iodine staining
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30
Q

Types of hysterectomy

Querlow and morrow

A

© Type A: Minimum Resection of Paracervix This
is an extrafascial hysterectomy.
© Type B: Transection of the Paracervix at the
Ureter This type has two levels:
B1-Without removal of lateral paracervical
lymph nodes
© B2-With removal of lateral paracervical
nodes
At least 10 mm of the vagina from the cervix
or tumor is resected.
• Type C In type C, the paracervix is transected
at the junction with the internal iliac
vascular system and has two types:
© C1-With nerve preservation
C2-Without preservation of autonomic
nerves
The ureter is mobilized completely, and 15
to 20 mm of vagina from the tumor or cervix
and the corresponding paracolpos is resected
routinely
© Type D In type D, the entire paracervix is
resected:
• D1-Resection of the entire paracervix along
with the hypogastric vessels
• D2-Resection of the entire paracervix, along
with the hypogastric vessels and adjacent
fascial or muscular structure

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31
Q

Radical hysterectomy tyoe

A

C1

Modified is b

32
Q

Radiation dose in cervic ca

A

80Gy

33
Q

Slnb in ca cervix when size less than

A

2cm

34
Q

Gardasil 9 includes

A

31
45
48
52

35
Q

Earliest abn in ca cervix

A

Blurring of stromoepithelilanjunctiok with protrusion of cells into stoma

36
Q

Senticol trial

A

Sentinel lnb in ca cervix

37
Q

Lilacs

A

Lnd in lacacervix

38
Q

Chemo in ca cervix

A

Cisplatin

If not then carbo

39
Q

Chemo in ne cervic ca

A

Cisplatin etoposide

Carbo

40
Q

Tests for mets or recurrent ca cervix

A

MSI
NTRK
PDL1

41
Q

How many ca endometrium before menopause

A

20%

42
Q

Msi mc in ca endometrium

A

Mlh1> msh6

43
Q

Mc histology in ca endometrium

A

Endometrioid

44
Q

Abn thicknes of endometrium

A

5 mm

45
Q

Use of ca125 in endometrial ca

A 
Use of CA 125 in endometrial cancer A
• Pelvic node mets
© Para aortic node mets
© Predicting treatment response
© Surveillance
© Extra uterine disease
46
Q

Most aggressive histology in ca endo

A

Serous aka uterine ppilalry serous cancer

47
Q

Mskcc prognostic factors in nomogram for ca endometrium

A 
Age at dx
Neg ln
Stage
grade
Histology
48
Q

Type 1 endo ca

A 
> Type 1 with hyper oestrogenism like
anovulatory bleeding, infertility, late
menopause and endometrium hyperplasia.
© Good prognosis
© Well differentiated
• Less invasion
© PI3K/AKT
49
Q

Type 2 endo ca

A 
• Type 2 lack hyperoestrogenism , older
© Poorly differentiated
© Extrauterine spread
© P53 p16
© In addition to TP53 mutations, type II
endometrial cancers are characterized by
HER2/neu amplification, loss of ER/PR, and
loss of E-cadherin.
50
Q

Future 1 and 2 trials

A

Guardasil

51
Q

Patricia and costarica hpv trial

A

Cervarix

52
Q

Complex hyperplasia with atypia risk of endo ca

A

30%

53
Q

Endometrial ca in atypical hyperplasia hysterectomy sample

A

42%

54
Q

Mc cause of death in ca cervix

A

Uremia

55
Q

High intermediate risk ca endo

A

NIf HIR per GOG 249: age 50-69 y with two risk factors or age <50 y with three ris
factors, or age 270 y with one risk factor. Risk factors include grade 2 or 3, deptr
of invasion to outer half, and LÜSI.

56
Q

Radical hysterectomy from which stage in ca endo

A

2

57
Q

Portec trial

A

Endometrium ca

58
Q

Endomteroid ca gentic clases 4

Molecular markers

A 
Mc and excellent prognosis -pole hyper mutation 
High copy number worst prognosis 
Copy number low beta catenin mutation
Msi hyper mutation
Markers- her2 ntrk erpr
59
Q

Endo ca clear cell type 4 molecular types

A

Pole
Mismatch repair deficient
Copy number high and low

60
Q

Ca endo metrium slnb

A

Done when limited to uterus without mets
Injected into cervix
Mc involves ventral to hypogastric
Medial to ext ilic and superior to obturator

61
Q

Er staging done when in ca endo

A

Stage 3,4 recurrent

62
Q

Her2 in ca endo tested when

A

Recurrnt

Serous

63
Q

Paraortic surgical stagin in endo ca

A 
Advanced stage
High grade
Clear cell
Serous
And carcinosarcoma
64
Q

Fertilitpreservation in ca endometrium

A 
Wd endometrioid G1
Linited to endometrium 
No mets no nodes
No ci to medica tt or pregnancy
Continous progestin based  for 6 m to 1 yr- megestrol medroxyprog
levonorgestrel iud
65
Q

Mc site of neuroendocrine ca in female GUT

A

Cervix

66
Q

G1 in endoca how much solid sheets

A

Endometrioid <5% solid sheets g1
G2- adeno ca 6-50%
G3- >50%

67
Q

Mixed mullerian tr

A

Carcinosarcoma
Riskfactor
Radiation and tamoxifen

68
Q

Mc sarcoma in endo

A

Lms

69
Q

Higrsde endometrstromal sarcoma fusion?

A

YEHAE NUTM 2A/B

70
Q

Node postivity in lms ess

A

3C

71
Q

Hormonal therapy in uterine sarcoma for

A

Low grade ess

And receptor postive lms

72
Q

Lms in uterine markers

A

Sma
Desmin
Plag1 + inmyxoid
Hmb45 and melan A neg

73
Q

Low garde ess positve markers

A

Jazf1 suz12
Er pr
Cd10

74
Q

Drug for sarcoma uterine

A

Doxo

75
Q

Endo carcin ct

A

Paclicarbo

Crash (20 decks)

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