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Crash > Renal Ca > Flashcards

Renal Ca Flashcards

1
Q

Risk factors of rcc

A 
Tobacco
Obesity
Hypertension
Esrd with acquired cystic ds
Hereditary
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2
Q

Mc type of RCC

A 
CLEAR CELL%75- prox tubule 
Papillary 15 prox tub
Chrome phobe
Oncocytoma 5 each from distal 
Collecting duct less than 1 %
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3
Q

How many pt undergoing dialysis develop acquired cystic disease kidney

A

40-50%

5.8% of those cysts dvelop rcc mc papillary

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4
Q

Which familial rcc aw clear cell histology

A 
Vhl-3p ✅
Hereditary papillary rcc 7q
Hereditary leiomyomatosis rcc 1q
Birt hogg dube 17p11
Sdh ✅
TSC9q 16p
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5
Q

C met gene asso with

A

Hprc

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6
Q

Which rcc affects m=f with excellent prognosis

A

Chromophobe

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7
Q

Rcc mc in women

A

Mucinous tubular

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8
Q

Sundrome with uterine fibroids early pmset
Adtenal hyperplasia
Kidney cancer

A

Hlrcc

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9
Q

.Immuno PET using antibody against carbonic

anhydrase IX is useful in which subtype of RCC

A

Clear cell and papillary

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10
Q

Esrd which yr sceening start

A

3 yr

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11
Q

Bap1 tumor aw

A

Clear cell

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12
Q

Melanoma and hif1

A

MiTF

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13
Q

Screening-Rcc

A

Vhl and hlrcc

From 16 yr

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14
Q

HGF aw

A

Papillary type

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15
Q

Xp RCC

A

Papillary

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16
Q

Rcc in cowden

A

Papillary
Pten
Killin mutations

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17
Q

How many ct enhancing lesions are benign-rcc

A

20%

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18
Q

Plant cells seen in

A

Chromophobe
Positive hales colloid iron stain
CK7 esinophilic subtype

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19
Q

Plant cell

A

Chromophobe

Positive hales colloid iron stain

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20
Q

Hyper vascular tumors

A

Clear cell

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21
Q

Multicentric rcc

A

Papillry

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22
Q

Best prognosis

A

Papilary 1

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23
Q

Mc paraneoplastic

A

Elevated esr

24
Q

Stauffers syndrome whats elevated

A

ALP

25
Q

Absolute ci for cytoreductive nephrectomy

A

Brain mets
Poor performanxe status
Relative- non clear cell

26
Q

Mskcc prognostic system

A 
Low karnofsky
High ldh
Low hb
High ca
Time from dx to tt less than 1 yr
27
Q

Imdc

A 
Low karnofsky
Low hb
High ca
Time  les than 1 yr
High neutro
High platelet
28
Q

Radical mephrectomy

A

Robson

29
Q

Partial nephrectomy normal percentage left behind in solitary

A

20-30%

30
Q

Prevalence of ln mets on rcc

A

6%

31
Q

Partial nephrectomy indication

A 
Indication
• Small unilateral tumors (Tia, selected Tib)
• Tumor in
• Uninephric state
• Renal insufficiency
• Familial tumor
• Bilateral tumor
Note- Tra-*tumor 4cm or less limited to kidney
Tib > tumor >4cm but not >7cm limited to
kidney
Stage I > T1 NO MO
Renal vein thrombus not a ci
32
Q

Local recurrence after prtial nephrectomy

A

3-5%

33
Q

Surveilance after thermal ablation rcc

A

Annual cxr
6 m mri
3 m ct

34
Q

• In Small incidentally diagnosed renal tumours what
percentage of tumours will have zero radiographic
growth in 36 months

A

30%

35
Q

Linear volumetric growth of radiologically localised small rcc

A

0.3cm per yr

36
Q

Surveillance size cut of

A

Solid tumors 2 cm
Cystic 4 cm
Familial 3 cm

37
Q

Highest response chemo in mets rcc

A

Lenvatenib

38
Q

Pref drug for clear cell

A

Axitinib + pembrolizumab
• Cabozantinib + nivolumab
• lenvatinib + pembrolizumab®

39
Q

Pref regime for nonclear cell

A

Cabozantinib

Sunitinib

40
Q

Maligannt features in ivu

A

Calcification within the mass
•increased tissue densit
• Irregular margins
• Distortion of collecting system

41
Q

Hu less than 20 solid mass negative attenuation

A

Aml

42
Q

Rcc if contrast more than hu?

A

15

43
Q

Sestamini pet used in which rcc

A

Chromophobe

44
Q

Radical nephrect criteria

A

, RN is preferred if all of the following criteria are met:
(1) high tumor complexity and PN would be
challenging even in experienced hands;
(2) no preexisting chronic kidney disease (CKD) or
proteinuria; and
(3) normal contralateral kidney and new baseline
estimated glomerular filtration rate (eGFR) will likely
de >45 mL/min/1.73 m2

45
Q

Ariser trial
Everest trial
Prosper trial
Immotion trial

A

Girentuximab
Everolimus
Nivolumab
Atezolilumab

46
Q

Carmena

Surtime trial

A

Targeted therapy sunitinib and cytoreductive nephrectomy

47
Q

Uiss

A

Tnm
Performance
Tr grade

48
Q

Mc tumor mets to kidney is from

A

Lung

49
Q

Chemo indicated in rcc

A

Chromophobe and medullary
Carbo gemcit
Paclicarbo

50
Q

Genetic screening indication in rcc

A 
Dx les than or eq 46 yrs
Bil or multifocal tr
One or more first or second degree relative with rcc
Histology - multifocal papillary 
Hlrcc 
Bhd 
Aml tsc
Sdh
51
Q

Everolimus prophylaxis

A

Aml tsc more than 3 cm

52
Q

Tumor ablation highest for

A

Posterior lesions

53
Q

Tumor venous thrombus levels in rcc

A 
0- renal vein
1- ivc less than 2 cm above rv
2- more than 2 cm but below hep vein
3- to or above hep v but below diaphragm
4- above diaphragm
54
Q

Ln d done in rcc ?

A

Children or young adults

55
Q

Markers of rcc

A

Cc rcc- ca 9

Aquaporin1 and perilipin 2

Crash (20 decks)

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