Sarcodosis

Question 1

Pathophysiology of sarcodosis?

Answer 1

Immunological disorder that causes lots of small nodules throughout the body

Is where body trying to do a immune response but there is no pathogen so it keeps repeating + going haywire.

Question 2

Risk factors of sarcodosis?

Answer 2

African american woman

Genetic family have it

Prior infection to myobacterium tuberculosis.

Question 3

What happens during sarcodosis?

Answer 3

Normally hillary lymph nodes by lungs are affected. so when the immune response keeps happening the macrophages + T cells join and form a granuloma. The granuloma are non ceasating ( means no necrosis at centre unlike tuberclosis)

Also macrophages can join and form a cell called langhan giant cells.

These cells contain schaumann bodies + asteroid bodies.

Question 4

Complications of sarcodosis?

Answer 4

Bilateral hilary lymphadenopathy

Erythema nodosum ( skin nodules)

Uvetis ( inflammation under cornea of eye)

Heart arrythmias

Question 5

Diagnosis of sarcodosis?

Answer 5

Chest X-ray:
- Bilateral hilar lymphadenopathy

Blood test:
- Increase calcium
- Increase ACE ( angiotensin converting enzyme)

Question 6

Symptoms of sarcodosis?

Answer 6

Fever
Weight loss
Fatigue
Shortness of breath
Vision change

Question 7

Treatment of sarcodosis?

Answer 7

Resolves after few weeks

If really bad steroids