Salmonella Flashcards
What is the only salmonella enterica to cause illness in humans
Salmonella enterica subsp. enterica
What are the serovars of salmonella enterica subsp. enterica based on
Somatic, flagellar, and capsular antigens
What are the two serovars most commonly associated with foodborne illness
Typhimurium and enteritidis
How do you serotype salmonella
Used to be done through reactions with antisera, now based on whole genome sequencing
How are salmonella serovars generally named
By their geographic origin
How can S enteritidis be transmitted
It can infect the ovaries of poultry and can be transmitted through eggs and undercooked poultry
What cells does salmonella infect
Phagocytic intestinal cells (M cells and dendritic cells) and non-phagocytic epithelial cells
What SPI’s encode adhesions needed for salmonella infect
SPI-3 and SPI-4
What does SPI-3 encode
MisL - binds to fibronectin on epithelial cells
MgtCB - involved in intramacrophage survival
What does SPI-4 encode
SiiE - mediates attachment to epithelial cells
What is a T3SS
A protein appendage found in gram negative bacteria
Pyroptosis
Highly inflammatory form of programmed cell death that occurs upon infection with intracellular pathogens
What does SPI-5 encode and what are their functions
SopE, SopE2, SigD
Lead to cytoskeletal remodeling and induction of proinflammatory response
Typhoid strains examples
Thypi and paratyphi
Non-typhoid strain examples
Thyphimurium, enteriditis
