Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Food-Borne Pathogens > Prions > Flashcards

Prions Flashcards

You may prefer our related Brainscape-certified flashcards:
Gourmet Food flashcards
1
Q

What is BSE called when it is transmitted to humans

A

Creutzfeldt-Jakob Disease (CJD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

When was the practice of feeding agricultural waste to animals banned

A

1988

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Prion definition

A

Infectious agents made of protein material that can fold multiple abstract ways and at least one of which is transmissible to other prion proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Prions composed of what protein are the cause of TSE

A

Prion protein PrP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How do prions cause disease

A

Converting PrPC into aggregation-prone PrPSc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Strain

A

A defined prion population isolated from one specific animal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Type

A

Refers to a combo of biochemical parameters (size of unglycosylated PrPSc fragment after proteinase K partial digestion) that are independent from the host

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Common characteristics of TSE disease

A

Long incubation periods, illness of weeks to months, PrPTSE accumulation in brain and other tissues, pathological changes confined to CNS, absence of immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Scrapie affects…

A

Sheep and goats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Chronic wasting disease affects…

A

Cervids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Transmissible mink encephalopathy affects…

A

Mink

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Kuru affects…

A

Humans (historical)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Different strains of TSE cause what conditions

A

Scrapie, chronic wasting disease, TME, kuru

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the incubation period of CWD

A

2-4 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where can PrPSc be found in CWD

A

Extraneural tissues, body fluids, and excreta (horizontal transmission is possible, one of the most contagious)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is unique about CWD transmission

A

Indirect transmission occurs via CWD prion deposition into environment from urine, feces and saliva

17
Q

How is BSE thought to arise in cattle

A

Genetic mutation

18
Q

What is needed to inactive the BSE protein

A

Immersion in 1N NaOH or a dry heat at 1000C (very stable protein)

19
Q

Symptoms of BSE

A

Degeneration of nervous system, changes in temperament, abnormalities in posture, nervousness and aggression, incoordination, tremors, hard to stand

20
Q

What is the incubation of BSE

A

2-8 years

21
Q

How long do clinical symptoms of BSE last

A

2 weeks to 6 months

22
Q

Who was most afflicted by variant CJD

A

Adolescents (occasional cases in adults over 50)

23
Q

What is the clinical presentation/duration of vCJD

A

Psychiatric disturbance and complaints of sensory symptoms like limb pain
Duration 14 months

24
Q

3 regulations to control BSE

A
  1. Feed bans
  2. Specified risk materials bans (removed brain and spinal cord and destroy)
  3. Regulation of rendering (autoclave slaughter materials)

Food-Borne Pathogens (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions