Salamat D.O.C Flashcards
Cyanide poisoning
Nitrite
Nitrite MOA
induces Methemoglobin formation
Nitrates in Angina
MOA: - Decrease in systemic vascular resistance - Vasodilates & Venodilates S/E: headache CI: Sildenafyl (Viagra)
Malignant Hyperthermia DOC:
Dantrolene
-Succinylcholine
Pheochromocytoma
DOC:
- Phenoxybenzamine
- Phentolamine
Acute Gouty Arthritis DOC
Colchicine
Colchicine MOA
Inhibits Microtubule assembly
Chronic Gout DOC
Allopurinol
Allopurinol MOA
Inhibit Xanthine oxidase
Rheumatoid Arthritis + History of Peptic Ulcer
COX inhibitor
If (+) allergy to Penicillin give
Erythromycin
If (+) GI upset to Erythromycin
If (+) GI upset to Erythromycin
Still with allergy give
Linezolid
Choriocarcinoma DOC
Methotrexate
Methotrexate MOA
Inhibit Dihydrofolate reductase
Breast + Ovarian Ca DOC
Paclitaxel
Islet Cell Tumor DOC
Streptozocin
AML DOC
Cytarabin
Auer Rods
AML
Pancreatic Ca & Colon Ca DOC
5 FU
5 FU MOA
Inhibit thymidylate synthase
Bronchogenic Ca DOC
Cisplastin / Cyclophosphamide + Etoposide
-S/E: Hemorrhagic Ca
oTx: Mesna
Cisplatin Side effect
oOtotoxicity
oNephrotoxicity
Anti-neoplastic for Brain Tumors
- Nitrosureas
- Lunostin, Corbostyl
iron Toxicity
Desferoxamine
Hemosiderosis
- > 5 grams Iron/day
- Multiple drug transfusions