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mic cabatu last ditch > Enzymes > Flashcards

Enzymes Flashcards

1
Q

Alpha 1 Anti-trypsin

A

Panacinar Emphysema

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2
Q
  • Gargoyle
  • Hurler’s disease
  • Corneal Clouding
  • Zebra bodies
A

Alpha-Lidurodinase

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3
Q

Iduronarale – Sulfatase

A

-Hunter’s disease
oMilder form of Hurler’s
-X – linked

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4
Q

-Bubble boy disease
-Severe combined immune deficiency
-Defect B cells ( HUMORAL Immunity) &
T Cells ( Cell Mediated Immunuty)

A

Adenosine Deaminase

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5
Q

Di George Syndrome

CATCH 22

A 
T cell defect
Thymic hypoplasia
Deletion of Chromosome 22
C – cardiac problem
A – abnormal facies
T – thymic hypoplasia
C – cleft Palate
H - hypocalcemia
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6
Q

Most common Immunodeficiency world wide?

A
  • Isolated IgA

- Associated with B cell deficiency

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7
Q

Most common Glomerulonephritis

A

IgA

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8
Q

Most common immunodeficiency in the Philippines

A
  • SCID (Severe Combined Immunodeficiency)
  • Infection of B & T cells
  • Worst prognosis
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9
Q

Hepatitis – World Wide

A

Alcoholic Hepatitis

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10
Q

Undernourished child with recurrent infection / & low immune system?

A

SCID

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11
Q

Wiskott Aldrich

A
  • Eczema

- Thrombocytopenia

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12
Q

Ceraminidase

A
  • Periarticular & subcutaneous swelling & progressive anthropathy
  • Farber’s disease
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13
Q

Alpha Glucosidase / Acid Maltase

A
  • Pompe’s disease
  • Type 2
  • Early onset heart failure
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14
Q

Heparin – N – Sulfatase

A

San Filippo disease

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15
Q

Spingomyelinase

A

Nieman Picks Disease

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16
Q

Β – Galactosidase

A
  • Coloboid Cell Leukodystrophy

- Krabbe disease

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17
Q

Phytamoyl – CoA Hydroxylase

A

Refsum’s Disease

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18
Q

Phytamic Acid

A

Refsum’s Disease

19
Q
  • Menkes disease
  • Kinky or Steely-Hair disease
  • Polo torti
A

Copper Dependent Enzyme Deficiency

20
Q

Copper Deficiency

A
  • Wilson’s Disease

- Menke’s disease

21
Q

NADH Oxidase

A
  • Chronic granulomatous disease (CGD)
  • Respiratory burst
  • Defective neutrophils
22
Q

Pyruvate dehydrogenase

A

Alper’s disease

23
Q

Cytochrome Oxidase

A

Cyanide

24
Q

Reverse Transcriptase

A

HIV

25
Q

Enzyme that Catalizes the transcription of DNA to synthesize precursor of MRNA

A
  • RNAP or POL II

- RNA Polymerase II

26
Q
  • Joins Okazaki fragments

- Seals DNA nicks

A

DNA Ligase

27
Q
  • DNA gyrase

- Responsible for negative supercoils

A

Topoisomerase

28
Q
  • Positive supercoils

- Unwinding of DNA

A

Helicase

29
Q

-Thermostable DNA polymerase
-Heat stable
-Used in PCR (Polymerase Chain Reaction)
-Bacteriua: Thermus aquaticus
-Frequently used in PCR
oA method for greatly amplifying short segments of DNA

A

TAQ Polymerase

30
Q

What is the laboratory reagent utilizing an Oxidative Enzyme from several other species of Fireflies?

A

Firefly Luciferase

31
Q

Luciferase

A

Genetic term for the term for the class of osidative enzyme used in bioluminescence & distinct from a photoprotein

32
Q
  • –Proofreading of DNA

- Bacterial RNA polymerase

A

Exonuclease

33
Q

initiation

A

SIGMA Factor

34
Q

Termination

A

Rho Factor

35
Q

Rate limiting enzyme in Heme Porphyrin Synthesis

A

ALA Synthase

36
Q
  • Catalizing carboxylation of pyruvate to oxaloacetate

- Anaplerotic reaction

A

Pyruvate Carboxylase

37
Q

-Protects RBC from oxygen free radicals
-Require SELENIUM
o Vitamin E protects RBC
o Synergistic to SELENIUM

A

Glutathione Reductase

38
Q

Rate limiting enzyme in UREA CYCLE

A

Carbomoyl PO4 Synthetase 1

39
Q

-Inhibit PFK

A

Sodium Stibogluconate

40
Q

Treatment for Leishmaniasis

A

Sodium Stibogluconate

41
Q

Disulfiram Reaction

A

Aldehyde Dehydrogenase

42
Q

Enzyme that inhibits steroid

A

Phospholipase A2

43
Q
  • Inhibit RENAL DIHYDROPEPTIDASE INHIBITOR
  • Prevents degradation of IMIPANEM
  • Imipanem + Cilastatin
A

Cilastin

44
Q

Carbidopa prevents the peripheral carboxylation of LEVODOPA (does not reach the brain)

A

Carbidopa + Levodopa

mic cabatu last ditch (23 decks)

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