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BodyLog * > S7 Haematopoeisis > Flashcards

S7 Haematopoeisis Flashcards

1
Q

What is the process of erythrocyte development?

A

Common myeloid progenitor - immature blast cells - reticulocytes - erythrocytes

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2
Q

What is the hormone that stimulates erythrocyte maturation and where is it found?

A

Erythropoietin

As foetus - liver
After birth - kidney

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3
Q

What happens to the nucleus and RNA is RBC’s?

A

Nucleus is lost over time and RNA is reduced over time (remaining RNA makes Hb)

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4
Q

What is the process off granulocyte development?

A

Common myeloid progenitor - myeloblast - granulocyte

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5
Q

What chemical messenger stimulates neutrophil development? And where is it released from?

A

G-CSF

Liver

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6
Q

What are the 3 granulocytes?

A

Neutrophils, basophils and eosinophils

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7
Q

What is the nucleus in basophils like and what do they do?

A

Have a bilobed nucleus (hidden by granules)

Contain histamine and heparin granules which trigger inflammation (e.g. vasodilation)

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8
Q

What is the nucleus in neutrophils like and what do they do?

A

Multilobed nucleus

Antigen-presenting cell (has neutrophil extracellular traps (NETs) that trap pathogens)
Can also phagocytose (aided by multilobed nucleus)

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9
Q

What is the nucleus in eosinphils like and what do they do?

A

Has 2 nuclear lobes

Fights parasitic worms - granules contain antihelminthic proteins for this
Can also phagocytose

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10
Q

What is the process of monocyte development?

A

Common myeloid progenitor - myeloblast - monocyte

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11
Q

What is the nucleus in monocytes like and what do they do?

A

Unilobular

Phagocytose and present antigens
Monocytes are like macrophages (only macrophages are in tissues nad monocytes are in blood)

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12
Q

What is the process of platelet development?

A

Common myeloid progenitor - megakaryocyte - platelets

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13
Q

What hormone stimulates platelet development and where is it found?

A

Thrombopoietin

Liver

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14
Q

What do platelets do?

A

Enable blood clotting/stop bleeding due to receptors on their surfaces causing platelet aggregation at a wound site.

(Have no nucleus)

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15
Q

What is the process of lymphocyte development?

A

Common lymphoid progenitor - small lymphocyte (and NK cells) - T lymphocyte and B lymphocyte - plasma cells (B cells only)

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16
Q

What hormone stimulates lymphocyte development?

A

Interleukin

17
Q

What do B cells do?

A 
Produce antibodies (involved in humoural response)
Activate T cells
18
Q

Where do B cells mature?

A

Peyer’s patches in intestine, spleen and lymph nodes

19
Q

What do T cells do?

A

Kill virus-infected cells, activate B cells using interleukin

20
Q

Describe the movement of T cells from being immature cells to being ready for activation.

A

Immature cells in bone marrow/feral liver

Mature in the thymus

Ready for activation in the secondary lymphoid organs

BodyLog * (16 decks)

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