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DRUGS > RSL - GI - Regulatory substances > Flashcards

RSL - GI - Regulatory substances Flashcards

1
Q

Gastrin: source

A

G cells; Antrum of stomach, duodenum

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2
Q

Gastrin; regulation

A

(increase) Stomach distention, AA, peptides, vagal stim, chronic PPI use

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3
Q

Somatostatin: source

A

D-cells: Pancreas, GI mucosa

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4
Q

Somatostatin: action

A

Decrease: Gastric acidd and pepsinogen, pancreatic and small intestine fluid secretion, Gall bladder contractility, Glucagon/insulin

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5
Q

Somatostatin: regulation

A

Increase by acid

Decrease by vagal stim

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6
Q

Cholecystokinin: Source

A

I cells: Duodenum, jejunum

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7
Q

Cholecystokinin: Action

A

increase: pancreatic secretions, gallbladder contration, relaxation of sphincter of oddi
Decrease: gastric emtying

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8
Q

Cholecystokinin: regulation

A

INcrease by: Fatty acids, AA

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9
Q

Secretin: source

A

S cells: duodenum

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10
Q

Secretin: Action

A

Increase: HCO3- secretion, Bile secretion
Decrease: Acid secretion

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11
Q

Secretin: Regulation

A

Increase: acid, FA in duodenum

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12
Q

Glucose-dependent insulinotropic peptide (GIP): Source

A

K-cells, duodenum and jejunum

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13
Q

Glucose-dependent insulinotropic peptide (GIP): action

A

Exocrine: decrease gastric H+ secretion
Endocrine: increase insulin

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14
Q

Glucose-dependent insulinotropic peptide (GIP): regulation

A

Increased by: FA, AA, oral glucose

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15
Q

Motilin: source

A

Small intestine

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16
Q

Motilin: action

A

produces MMCs

17
Q

Motilin: Regulation

A

increased in fasting state

18
Q

VIP: source

A

PSNS ganglia in sphincters, gallbladder, small intestine

19
Q

VIP: Action

A

Increase: intestinal water, and electrolytes (HCO3-, Cl-), relaxation of intestinal smooth muscle and sphincters
Decrease: H+ secretion

20
Q

VIPoma

A

Non-alpha, non-beta islet cell pancreatic tumor:

Copious watery diahrea, hypokalemia, Achlorhydria (WDHA syndrome)

21
Q

NO loss

A

Loss is associated with LES tone (achalasia)

22
Q

Gastric acid: source

A

Parietal cells (stomach)

23
Q

Gastric acid: Regulation

A

increased by: histamine, ACh, gastrin

Decreased by: Somatostatin, GIP, prostaglandin secretion

24
Q

Pepsin: Source

A

Chief cells (stomach)

25
Q

Pepsin: action

A

Protein digestion

26
Q

Pepsin: regulation

A

increased by vagal stimulation and local acid

27
Q

HCO3-: source

A

Mucosal cells (stomach, duodenum, salivary glands, pancreas) and brunners glands

28
Q

HCO3-: Action

A

neutralizes action

29
Q

HCO3-: regulation

A

increased by pancreatic and biliary secretion with secretin

DRUGS (41 decks)

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