MICRO - Antimycobacterial drugs

Question 1

Isoniazid - MOA

Answer 1

Decrease synthesis of mycolic acid

Question 2

Isoniazid - Use

Answer 2

MTB prophylaxis and treatment

Question 3

Isoniazid - activation

Answer 3

KatG –> Catalase-peroxidase –> active metabolite

Question 4

Isoniazid - AE

Answer 4

Lupus like symptoms Decreased B6 –> Neurotoxicity, sideroblastic anemia

Question 5

Ethambutol - MOA

Answer 5

Blocks arabinosyl transferase –> decreased cell wall

Question 6

Ehtambutol - AE

Answer 6

Red green color blindness (optic neuropathy)

Question 7

Rifampin, Rifambutin - MOA

Answer 7

DNA - Dependent RNA polymerase inhibition

Question 8

Rifampin, rifambutin - AE

Answer 8

Orange fluids

Question 9

Rifampin - AE

Answer 9

Orange fluids + CYP450 induction

Question 10

Ethambutol - Treats

Answer 10

MTB treatment

Question 11

Rifampin, rifambutin - Treats?

Answer 11

MTB treatment Mycobacterium leprae treatment H. influenza type B and meningococcal exposure prophylaxis

Question 12

Pyrazinamide - Treats

Answer 12

MTB treat

Question 13

Pyrazinamide - AE

Answer 13

Hyperuricemia

Question 14

M. Tuberculosis: Prophylaxis and Rx

Answer 14

Prophylaxis = INH

Rx = RIPE (rifampin/rifambutin, INH, Pyrazinamide, Ethambutol)

Question 15

MAC: prophylaxis and Rx

Answer 15

Prophylaxis = Azithromycin + rifambutin

Rx = Azithromycin Or Clarithromycin; + ethambutol. [can add rifambutin or cipro]

Question 16

M. leprae: Prophylaxis; tuberculoid Rx; lepromatous Rx

Answer 16

Prophylaxis = N/A!!!

Tuberculous = dapsone + rifampin

Lepromatous = dapsone + rifampin + clofazimine