RESP - drugs Flashcards
H1 blockers:
Gen 1: Diphenhydramine, dimenhydrinate, chlorpheniramine, hydroxazine, promethazine, meclizine
Gen 2: Loratidine, desloratadine, fexofenadine, cetirizine, astemazide, terfenadine
H1G1 blockers
Gen 1: Diphenhydramine, dimenhydrinate, chlorpheniramine, hydroxazine, promethazine, meclizine
H1G2
Gen 2: Loratidine, desloratadine, fexofenadine, cetirizine, astemazide, terfenadine
H1G1 blocker: MOA, use, AE
MOA:
- Reversible inhibition (inverse agonist)
use:
- Allergy
- motion sickness
- sleep aid
AE:
- Sedation
- anti-muscarinics
- anti-alpha adrenergics
- anti-5HT
Gen 1: Diphenhydramine, dimenhydrinate, chlorpheniramine, hydroxazine, promethazine, meclizine
H1G1 blocker: MOA, use, AE
MOA:
- Reversible inhibition (inverse agonist)
use:
- Allergy
- motion sickness
- sleep aid
AE:
- Sedation
- anti-muscarinics
- anti-alpha adrenergics
- anti-5HT
Gen 1: Diphenhydramine, dimenhydrinate, chlorpheniramine, hydroxazine, promethazine, meclizine
H1G1 blocker: MOA, use, AE
MOA:
- Reversible inhibition (inverse agonist)
use:
- Allergy
- motion sickness
- sleep aid
AE:
- Sedation
- anti-muscarinics
- anti-alpha adrenergics
- anti-5HT
Gen 1: Diphenhydramine, dimenhydrinate, chlorpheniramine, hydroxazine, promethazine, meclizine
H1G2 blocker: MOA, use, AE
MOA:
- reversible inhibition (partial agonist)
use:
- allergy
AE:
- less sedating because less entry into CNS
Gen 2: Loratidine, desloratadine, fexofenadine, cetirizine, astemazide, terfenadine
H1G2 blocker: MOA, use, AE
MOA:
- reversible inhibition (partial agonist)
use:
- allergy
AE:
- less sedating because less entry into CNS
Gen 2: Loratidine, desloratadine, fexofenadine, cetirizine, astemazide, terfenadine
H1G2 blocker: MOA, use, AE
MOA:
- reversible inhibition (partial agonist)
use:
- allergy
AE:
- less sedating because less entry into CNS
Gen 2: Loratidine, desloratadine, fexofenadine, cetirizine, astemazide, terfenadine
Expectorants
Guaifenesin
NAC
Guaifenesin: MOA
Expectorant: thins respiratory secretions (but does not suppress cough reflex)
NAC: MOA, use
Mucolytic - disrupts disulphide bonds to loosen mucus plugs in CF (also for acetominophen toxicity)
Dextromethorphan: MOA, use, AE
MOA:
- antagonizes NMDA-Rs; codeine analog
use:
- cough suppressant (antitussive)
AE:
- OD: give naloxone
- mild abuse potential
- Serotonin syndrome
Dextromethorphan: MOA, use, AE
MOA:
- antagonizes NMDA-Rs; codeine analog
use:
- cough suppressant (antitussive)
AE:
- OD: give naloxone
- mild abuse potential
- Serotonin syndrome
Dextromethorphan: MOA, use, AE
MOA:
- antagonizes NMDA-Rs; codeine analog
use:
- cough suppressant (antitussive)
AE:
- OD: give naloxone
- mild abuse potential
- Serotonin syndrome
Nasal decongestants:
Pseudoephedrine and phenylepherine
Nasal decongestants: MOA, use, AE
MOA:
- alpha-agonists (Pseudoephedrine = a1 + b2) and phenylepherine (a1), a1 causes VC
use:
- decreases hyperemeia, edema, and nasal congestion
- Opens ostructed eustatian tubes
AE:
- pseudoephedrine → CNS stimulation/anxiety and makes meth
- HTN
Pseudoephedrine and phenylepherine
Nasal decongestants: MOA, use, AE
MOA:
- alpha-agonists (Pseudoephedrine = a1 + b2) and phenylepherine (a1), a1 causes VC
use:
- decreases hyperemeia, edema, and nasal congestion
- Opens ostructed eustatian tubes
AE:
- pseudoephedrine → CNS stimulation/anxiety and makes meth
- HTN
Pseudoephedrine and phenylepherine
Nasal decongestants: MOA, use, AE
MOA:
- alpha-agonists (Pseudoephedrine = a1 + b2) and phenylepherine (a1), a1 causes VC
use:
- decreases hyperemeia, edema, and nasal congestion
- Opens ostructed eustatian tubes
AE:
- pseudoephedrine → CNS stimulation/anxiety and makes meth
- HTN
Pseudoephedrine and phenylepherine
Pseudoephedrine and phenylepherine
Pulmonary HTN drugs:
endothelin-R antagonist
PDE-5 inhibitors
Prostacyclin analogs
Endothelin-R antagonists: name, MOA, use, AE
Name: Bosentan
MOA:
- competitive antagonism @ ET-1-Rs [endothelin causes VC, so blocking then causes VD]
use:
- decrease pulmonary vascular resistance
AE:
- Hepatotoxicity (monitor LFTs)
- cant use in pregnancy
PDE-5 inhibitors: name, MOA, use, AE
Name: Sildenafil
MOA:
- inhibits cGMP PDE5 and prolongs VD effect of NO
use:
- pulmonary HTN
- ED
AE:
- flusing, hypotension
Prostacyclin analogs: names, MOA, use, AE
Name: epoprostenol, iloprost
MOA:
- PGI2 - DIRECT VD effect on pulmonary AND systemic ARTERIAL vascular beds
- inhibit platelet aggregation
use:
- Pulonary HTN
- systemic HTN
AE:
- JAW PAIN
- flushing
Asthma drugs: general mechanism
Decrease inflammatory pathway
Decrease PSNS tone
Asthma b2-agonists
Albuterol
Salmeterol
Formoterol
Albuterol use
acute asthma exacerbations (b2 ag)
Salmeterol use and AE
use: asthma prophylaxis, especially nocturnal (b2 agonist)
AE = loss of beta specificity: tremor, arrythmia, hyperglucemia, tachycardia
Salmeterol use and AE
asthma prophylaxis, especially nocturnal (b2 agonist)
AE = loss of beta specificity: tremor, arrythmia, hyperglucemia, tachycardia
Formoterol use and AE
use: asthma prophylaxis, especially nocturnal (b2 agonist)
AE = loss of beta specificity: tremor, arrythmia, hyperglucemia, tachycardia
Formoterol use and AE
asthma prophylaxis, especially nocturnal (b2 agonist)
AE = loss of beta specificity: tremor, arrythmia, hyperglucemia, tachycardia
Asthma corticosteroids: names, MOA, use, AE
names: Fluticasone, budesonide, flunisolide, beclomethasone
MOA
- inactivates NFKB (the TF for TNF-a)
- Inhibits synthesis of all cytokines
Use:
- chronic asthma
AE:
- oral thrush (decrease with mouth rince or spacer)
- dysphonia
Asthma corticosteroids: names, MOA, use, AE
names: Fluticasone, budesonide, flunisolide, beclomethasone
MOA
- inactivates NFKB (the TF for TNF-a)
- Inhibits synthesis of all cytokines
Use:
- chronic asthma
AE:
- oral thrush (decrease with mouth rince or spacer)
- dysphonia
Asthma corticosteroids: names, MOA, use, AE
names: Fluticasone, budesonide, flunisolide, beclomethasone
MOA
- inactivates NFKB (the TF for TNF-a)
- Inhibits synthesis of all cytokines
Use:
- chronic asthma
AE:
- oral thrush (decrease with mouth rince or spacer)
- dysphonia
Asthma corticosteroids: names, MOA, use, AE
names: Fluticasone, budesonide, flunisolide, beclomethasone
MOA
- inactivates NFKB (the TF for TNF-a)
- Inhibits synthesis of all cytokines
Use:
- chronic asthma
AE:
- oral thrush (decrease with mouth rince or spacer)
- dysphonia
ipratropium MOA and use
MOA: Competitive muscarinic antagonist, prevents bronchocontriction
Use: asthma and COPD
ipratropium MOA and use
MOA: Competitive muscarinic antagonist, prevents bronchocontriction
Use: asthma and COPD
Montelukast/Zafirlukast: MOA and use
Block LT-R (CysLT1) (LT C4, D4, E4)
ASA-induced asthma
Zileuton: MOA and AE
MOA = 5-LOX inhibitor
AE = hepatotoxicity
Omalizumab: MOA and use
MOA: monoclonal ANTI-IgE ANTIBODY; binds free IgE and blocks it’s binding to FcE-R1
Use: allergic asthma resistant to inhaled steroids and LABAs
Omalizumab: MOA and use
MOA: monoclonal ANTI-IgE ANTIBODY; binds free IgE and blocks it’s binding to FcE-R1
Use: allergic asthma resistant to inhaled steroids and LABAs
Theophylline: family, MOA, AE
Family: methylxanthines
MOA: inhibits PDE
AE:
- cardiotoxic (arrythmias)
- neurotoxic (seizures)
- metabolized by P450
- Blocks actions of adenosine
- tremor
- N/D; abdominal pain
Theophylline: family, MOA, AE
Family: methylxanthines
MOA: inhibits PDE
AE:
- cardiotoxic (arrythmias)
- neurotoxic (seizures)
- metabolized by P450
- Blocks actions of adenosine
- tremor
- N/D; abdominal pain
Theophylline: family, MOA, AE
Family: methylxanthines
MOA: inhibits PDE
AE:
- cardiotoxic (arrythmias)
- neurotoxic (seizures)
- metabolized by P450
- Blocks actions of adenosine
- tremor
- N/D; abdominal pain
Methacholine: MOA, use
M3 agonist - bronchoconstriction
Diagnose asthma
Cromolyn and Nedocromil: MOA, use, AE
MOA: mast cell stabilizers
use: asthma prophylaxis
AE:
- Cromolyn = laryngeal edema, cough, wheeze
- nedocromil = bad taste