[RRT] Flashcards
Blood over semi-permeable membrance
dialysis fluid opposite direction
diffusion down conc. gradient
disequilibration syndrome
neurological signs/symptoms
as a result of cerebral oedema
due to solute removal
HIGHLY permeable membrance
blood same direction as dialysate
large and small solutes
ultrafiltrate replaced concurrently
hypotension/haemodynamic instability
ultrafiltrate is replaced with the same volume of fluid in real time
takes too long
critically ill patient
less haemodynamic instability
peritoneum as semi permeable membrane
Tenckhoff
adding solutes to the dialysate e.g. glucose
can be carried out at home
exit site infection
PD induced peritonitis
loss of membrane function over time
hypertension
calcium dysregulation
phosphate dysregulation
Uraemia causes granulocyte dysfunction
amyloid accumulation deposition
haemodialysis/PD
increased loss in dialysate
high PTH
ESRF
anaesthetic - physically fit
active infection
cancer (unless cured >5yrs ago)
severe co-morbidity
DCD: donor after cardiac death
DBD: donor after brainstem death
LD: living donor
increased warm iachaemic time
The time a tissue remains at body temperature after its blood supply has been reduced or cut off but before it is cooled.
LD
T
basiliximab
anti-IL-2 receptor
triple therapy: calcineurin-i \+ anti-metabolite \+ prednisolone
tacrolimus
ciclosporin
aziathioprine
mycophenolate
prevents activation of T cells
purine analogue
inhibits enzyme which produce purines
T
alemtuzumab
no prednisolone
tacrolimus (/ciclosporin)
+
aziathioprine (/mycophenolate)
cervical smears
EBV –> post-transplant lymphoproliferative disorder
EBV
post-transplant lymphoproliferative disorder
cardiovascular - increased BP
agranulocytosis
hepatitis
gum hypertrophy
hirsutism
new onset DM after transplant
acute
chronic
Methylprednisolone IV high-dose
intensification of immunosupression
plasma exchange
donor specific Abs
