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RENAL > [nephrotic] > Flashcards

[nephrotic] Flashcards

1
Q
A

Proteinuria (>3.5g/day)
Hypoalbuminaemia (<25g/L)
Oedema

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2
Q
A

> 250mg/mmol

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3
Q
A

albumin: creatinine ratio

* ** add in meaning

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4
Q
A

hyperlipidaemia

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5
Q
A

reduced oncotic pressure of blood, increased hepatic triglyceride and cholesterol synthesis to compensate

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6
Q
A

total cholesterol >10mmol/L

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7
Q
A

Membranous
Minimal change
Mesangiocapillary
Focal segmental glomerulosclerosis

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8
Q
A

DM
Amyloidosis
SLE (5)
Hep B/C

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9
Q
A

membranous disease

Hep C can also –> MCGN

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10
Q
A

NSAIDs

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11
Q
A

NSAIDs
Penicillamine
anti-TNF

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12
Q
A

podocytes

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13
Q
A

maintain the filtration barrier

i.e. prevents large weight molecules from passing through

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14
Q
A

foot processes

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15
Q
A

pitting

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16
Q
A

low tissue resistance (also legs - relative low resistance due to gravity)

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17
Q
A

no - mild or normal

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18
Q
A

no - mild raise or normal.

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19
Q
A 
CCF (oedema, proteinuria)
Liver failure (hypoalbuminaemia)
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20
Q
A

children

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21
Q
A

can be normal - hence the name

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22
Q
A

foot effacement

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23
Q
A

ACEi/ARB in all patients to reduce proteinuria

24
Q
A

Steroids

most relapse

25
Q
A

If patient undergoes frequent relapse

26
Q
27
Q
A

diffusely thickened GBM

28
Q
29
Q
30
Q
A

anti-phospolipase A2 receptor

31
Q
32
Q
A

some glomeruli have scarring

33
Q
34
Q
36
Q
A

collapsing tubule

37
Q
38
Q
A

steroid resistant

41
Q
A

minimal change

43
Q
A

no response to steroids

features suggest a different cause (e.g. haematuria –> nephritic)

45
Q
A

reduced - lost in urine

46
Q
A

increased susceptibility to infection

47
Q
A

loss of anti-coagulants in urine (anti-thrombin/protein s)

increase production of clotting factors from liver

48
Q
A

Protein s

Anti-thrombin

49
Q
A

reduce oedema
Reduce proteinuria
reduce complications
Treat cause

50
Q
A

Loop diuretics: furosemide

51
Q
A

Gut oedema preventing absorption

52
Q
A

limit fluid intake

53
Q
54
Q
A

independent of antihypertensive effect

increase nephrin levels (protein in filtration barrier) and realigns proteins in barrier

55
Q
A

reduce hypercholesterolaemia

56
Q
A

proteinuria >3.5g/day

57
Q
A

treat underlying cause

RENAL (14 decks)

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