[reno-vascular/HUS/TTP] Flashcards
1
Q
A
hyper
2
Q
A
atherosclerosis
fibromuscular dysplasia
anti-phospholipid syndrome
external compression
3
Q
A
Raised BP resistant to Tx
4
Q
A
worsening renal function with ACEi
5
Q
A
bilateral renal artery stenosis
6
Q
A
rapid onset pulmonary oedema
7
Q
A
renal artery stenosis
8
Q
A
affected
9
Q
A
renal angiography
not 1st - invasive
10
Q
A
CT/MRI
11
Q
A
angioplasty
stents
12
Q
A
Haemolytic uraemic syndrome
13
Q
A
MAHA
microangiopathic haemolytic anaemia
14
Q
A
intravascular haemolysis
RBC fragmentation
15
Q
A
endothelial damage
thrombosis
fibrin strand deposition
haemolysis of RBCs
16
Q
A
platelet consumption
17
Q
A
e.coli O157
18
Q
A
verotoxin damages endothelium
19
Q
A
undercooked meats
20
Q
A
abdominal pain
bloody diarrhoea
21
Q
A
schistocytes
22
Q
A
haematuria
proteinuria
23
Q
A
normal clotting
24
Q
A
renal vasculature
25
[reno-vascular]: HUS: if severe disease what may be indicated (2)
RRT
| Plasma exchange
26
[reno-vascular]: TTP: what does TTP stand for
thrombotic thrombocytopenic purpura
27
[reno-vascular]: TTP: there is a deficiency of what protein
ADAMTS13
28
[reno-vascular]: TTP: the protein which is abnormal is responsible for what action
cleaving multimers of WvF
29
[reno-vascular]: TTP: what is responsible for the aggregation of platelets and fibrin deposition (MAHA)
aggregating large WvF proteins
30
[reno-vascular]: TTP: what are the 5 clinical features of TTP?
```
MAHA
AKI
CNS signs
fever
thrombocytopenia
```
31
[reno-vascular]: TTP: Tx?
urgent plasma exchange - emergency
32
[reno-vascular]: TTP: Ix? (2)
```
Urine dipstick (haem, protein)
Film (schisto)
```
33
[reno-vascular]: DM: define microalbuminaemia
30-300mg albumin/24 hours
34
[reno-vascular]: DM: what is microalbuminaemia useful for prognosis
Prognosis for renal problems
35
[reno-vascular]: DM: what is microalbuminaemia an independent risk factor for?
CVS
36
[reno-vascular]: DM: do standard dipsticks check microalbuminaemia
no
37
[reno-vascular]: DM: how can you check microalbuminaemia
specialised dipstick
| ACR ratio
38
[reno-vascular]: DM: what ACR ratio relates to microalbuminaemia (same and proteinuria) (men and females)
>2.5 men
| >3.5 women
39
[reno-vascular]: DM: if microalbuminaemia is present what is 1st line Tx
ACEi/ARB
*always start ACE regardless of BP*
40
[reno-vascular]: DM: how frequently should DM patients be screened for microalbuminaemia
annually
