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RENAL > [diureticsMOA] > Flashcards

[diureticsMOA] Flashcards

1
Q
A

furosemide

Bumetanide

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2
Q
A

block Na+/K+/2Cl-
thick ascending
increase solute load intraluminally
reduction in h2o absorption

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3
Q
A 
Na+
K+ (hypokal)
cl-
H+ (met. alk)
Ca2+
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4
Q
A

Hypokalaemia
met. alkalosis
hypovolaemia
ototoxicity

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5
Q
A

oedema of stria vacularis

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6
Q
A

x40

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7
Q
A

yes

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8
Q
A

inhibit Na+/Cl-

distal convoluted tubule

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9
Q
A

lowered

i.e. increase calcium reabsorption

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10
Q
A

Na+
Cl-
^^^K+ (profound)
Mg2+

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11
Q
A

uric acid

calcium

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12
Q
A

12 hours duration

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13
Q
A

YES - reduced urinary calcium (not related to serum level)

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14
Q
A

gout

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15
Q
A

decreased urate acid exrcetion

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16
Q
A 
Hypokalaemia
Hyponatraemia
Hypomagnesaemia
met alkalosis
urate increased
hyperglycaemia
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17
Q
A

SE is hyperglycaemia

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18
Q
A

spironolactone
eplerenone

Amiloride
Triamterene

19
Q
A

spironolactone

eplerenone

20
Q
A

amiloride

triamterene

21
Q
A

Block Na+ in collecting duct

22
Q
A

inhibit aldosterone

aldosterone retains Na+

24
Q
26
Q
A

ameliorates K+ loss due to loop/thiazides

27
Q
A

K+

ameliorates K+ loss due to loop/thiazides

28
Q
A 
metabolic acidosis (H+ retention)
hyperkalaemia
29
Q
A

it inhibits androgen production

30
Q
A

GI upset

Gynecomastia

31
Q
32
Q
A

freely filtered at glomerulus
poorly reabsorbed in tubule
holds water by osmotic effect

33
Q
A

raised ICP
Brain volume reduction
intra-ocular pressure reduction
rhabdomyolysis

34
Q
A

Rhabdomyolysis

35
Q
A

pulmonary oedema

36
Q
A

transient expansion of extracellular due to extraction from intracellular –> pulmonary oedema

37
Q
A

Acetazolamide

38
Q
A

increase excretion of HCO3 and therefore Na+, K+, h2o

39
Q
A

alkaline urine

metabolic acidosis

40
Q
A

Glaucoma

not diuretic

41
Q
A

reduce formation of aqueous humour

42
Q
A

acidosis = increased respiration = improve acclimatization = reduced risk of acute mountain sickness

43
Q
A

Bicarbonate reabsorption in dependent on carbonic anhydrase inhibitors

RENAL (14 decks)

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