rocuronium zemuron

Question 1

drug classification

Answer 1

non depolarizing neuromuscular blocker

Question 2

mechanism of action

Answer 2

nicotinic ACh R antagonist- competes with ACh at neuromuscular junction and prevents binding, thus inhibiting skeletal muscle depolarization

Question 3

onset

Answer 3

60-70 sec

Question 4

peak

Answer 4

1-3 min

Question 5

duration

Answer 5

24-40 min

Question 6

half life

Answer 6

14-18 min

Question 7

indications, field use

Answer 7

need for temporary paralysis to facilitate endotracheal intubation
need for continued paralysis following endotracheal intubation

Question 8

contraindications

Answer 8

hypersensitivity

Question 9

side effects, adverse reaction

Answer 9

tachycardia, hypertension, hypotension, bronchospasm- rarely

Question 10

dose adult

Answer 10

0.6 -1.2mg/kg IV IO

Question 11

dose pedi

Answer 11

0.6mg/kg IV IO

Question 12

precautions

Answer 12

presence of neuromuscular disease may be associated with prolonged paralysis

Question 13

drug on drug interactions

Answer 13

potentiated by lidocaine, procainamide, beta blockers, k-sparing diuretics, magnesium sulfate and other neuromuscular blockers including succinylcholine