lorazepam ativan

Question 1

drug classification

Answer 1

benzodiazepine, hypnotic,anticonvulsant, sedative

Question 2

mechanism of action

Answer 2

positive allosteric modulator for GABA a receptors- binds to benzo receptor side on CL- channels and potentiates binding and effects of GABA- increases intracellular CL- concentration leading to hyperpolarization of cell

Question 3

onset

Answer 3

1-5 min IV IO, 15-30 min IM

Question 4

peak

Answer 4

15-20 min IV IO, 2 hours IM

Question 5

duration

Answer 5

6-8 hours

Question 6

half life

Answer 6

10-20 hours

Question 7

indication, field use

Answer 7

major motor seizure,
pre medication for TCP and cardioversion
acute anxiety
alcohol withdrawal/delirium tremens
post intubation sedation

Question 8

contraindications

Answer 8

hypersensitivity

Question 9

side effects, adverse reaction

Answer 9

hypotension, drowsiness, amnesia, respiratory depression, blurred vision, AMS, N+V

Question 10

dose adult seizure

Answer 10

4 mg IV IO

Question 11

pre medication/anxiety/withdrawal

Answer 11

0.5 2mg (0.1mg/kg) slow IV IO

1-4 mg IM

Question 12

post intubation adult

Answer 12

2-4 mg slow IV IO q 5-10 min

Question 13

pedi dose

Answer 13

0.05mg/kg slow IV IO

Question 14

precautions

Answer 14

may causes CNS and respiratory depression

caution with acute alcohol intoxication

Question 15

drug on drug interactions

Answer 15

additive effects with CNS depressants and alcohol