midazolam versed

Question 1

drug classification

Answer 1

benzodiazepine, anticonvulsant, sedative, hypnotic

Question 2

mechanism of action

Answer 2

positive allosteric modulator for GABA a receptors- binds to benzo receptor side on chloride channels and potentiates binding and effects of GABA- increased intracellular CL- concentration leading to hyperpolarizing of the cell

Question 3

onset

Answer 3

3-5 min IV IO , 15 min IM

Question 4

peak

Answer 4

20-60 min

Question 5

duration of effects

Answer 5

less than 2 hours IV IO, 1-6 hours IM

Question 6

half life

Answer 6

1-4 hours

Question 7

indications, field use

Answer 7

pre medication for TCP or cardioversion
post intubation sedation
seizures

Question 8

contraindication

Answer 8

history of narrow angle glaucoma

hypotension

Question 9

side effects, adverse reaction

Answer 9

hypotension, drowsiness,amnesia, respiratory depression, AMS, blurred vision, N+V

Question 10

dose adult pre medication

Answer 10

2-5mg (0.5mg/kg) slow IV IO IM

Question 11

dose adult post medication

Answer 11

2.5 mg q 5-10 min slow IV, IO

Question 12

adult seizure

Answer 12

2-6 mg IV, 10 mg IM 0.2mg/kg IN max of 10 mg

Question 13

pedi dose

Answer 13

0.2mg/kg slow IV IO, max dose 10 mg

Question 14

precautions

Answer 14

may cause CNS and respiratory depression

caution with acute alcohol intoxication

Question 15

drug on drug interactions

Answer 15

additive effects with CNS depressants and alcohol