atropine sulfate

Question 1

drug classification

Answer 1

anticholinergic, parasympatholitic

Question 2

mechanism of action

Answer 2

muscarinic ACh R antagonist- inhibits parasympathetic stimulation in SA and AV nodal cells- prevents potassium efflux and hyperpolarization-positive chronotropy, no inotropic effects

Question 3

onset

Answer 3

immediate

Question 4

peak

Answer 4

2-4 min

Question 5

duration

Answer 5

4 hours

Question 6

half life

Answer 6

2-3 hours

Question 7

indications, field use

Answer 7

symptomatic bradycardia
premedication for RSI with bradycardia with less than 50 bpm
organophosphate poisoning

Question 8

contraindications

Answer 8

none in emergency setting

Question 9

side effects, adverse reactions

Answer 9

blurred vision, dialated pupils, dry mouth, tachycardia, drowsiness, confusion

Question 10

dose bradycardia adult

Answer 10

0.5 mg slow IV IO q 3-5 min max of 3mg

Question 11

RSI adult

Answer 11

0.5 -1mg IV IO

Question 12

organophosphate poison adult

Answer 12

2-5 mg IV IO IM q 20-30 min until S/S resolve

Question 13

bradycardia pedi dose

Answer 13

0.02mg/kg IV IO minimum single dose of 0.1mg, max single dose 0.5mg

Question 14

RSI pedi

Answer 14

0.02mg/kg IV IO

Question 15

organophosphate poisoning child

Answer 15

0.05mg/kg IV IO IM q 20-30 min until S/S resolve

Question 16

precautions

Answer 16

do not give less than 0.5mg adult or 0.1 mg pedi - causes paradoxical effect
may cause paradoxical slowing or may be ineffective if used for 2nd degree type2/3 degree heart block
caution with acute MI- increases myocardia oxygen demand

Question 17

drug on drug interactions

Answer 17

few in ems