Robin Chapter 3

Question 1

What are NOD-like receptor (NLR)?

Answer 1

A cytosolic receptor that detect molecules that are liberated as a consequenence of cell dammage

Question 2

What are the 5 R of inflammatory response steps?

Answer 2

Repair, Regulation, REmovl of the agent, Recruitement, REcognition

Question 3

How does histamine (and bradykinin, leucotrienes, etc) cause vascular permeability of postcpillary veinules?

Answer 3

Contraction of endothelial cells. It is short-lived (15-30 min) except in some forms or mild injury like burns, UV, toxins where leakage begins after 2-12 hours and last for hours of days (endothelial injury)

Question 4

What is the role of those proteins in migration of leucocytes through the capillaries?
- selectin
- chemokins (usually bound to proteoglycans)
- integrins
- CD31

Answer 4

• selectin: rolling
• chemokins/proteoglycans: acivating neutrophils to increase avidity of integrins
• integrin: firm adhesion
• CD31 (PECAM-1): transmigration

Question 5

P-selectin is expressed on…. (2)

Answer 5

endohelium and platelet

Question 6

Chemotactic agents (cytokines, complement (C5a), archidonic acid metabolites like LTB4) bind to which receptor on the leucocyte?

Answer 6

seven-transmembrane G protein-coupled receptors