Robbins chapitre 4

Question 1

How long does it take for necrosis to show microscopically?

Answer 1

4-12 hours

Question 2

Definition of shock

Answer 2

circulatory failure that impairs tissue perfusion and leads to hypoxia

Question 3

GRAM + or GRAM - causes most often sepsis?

Answer 3

GRAM +

Question 4

Which molecule blunts the vasomotor response in shock, causing vasodilatation instead of compensory vasoconstriction?

Answer 4

lactic acid

Question 5

Which are the major types of shock:

Answer 5

cardiogenic hypovolemic, septic (and systemic inflammatory response syndrome, caused by burns, trauma, pancreatis, so non microbial insults)

Less frequent: neurogenic (spinal cord injury) and anaphylactic

Question 6

Give 3 roles of thrombin in hemostasis and cellular activation (what they activate, what they deposit…)

Answer 6

• deposition of fibrin and platelet aggreggation on endothelial injury
• neutrophil adhesion
• monocyte activation
• lymphocytes activation
• endothelial activation