Robbins chapter 2

Question 1

Which caspases are activated in the intrinsic apoptosis pathway and the extrinsic one and the pyroptose

Answer 1

caspase-9

caspase 8, caspase 10

caspase 1

Question 2

Name 2 things that the caspases activated in the execution phase do

Answer 2

1. cleavage of an inhibitor of DNase. Then DNase is enzymatically active and DNA start to degrade
2. Proteolyzation of the structural components of the nucler matrix

Question 3

what is efferocytosis

Answer 3

phagocytosis of apoptotic cells

Question 4

which apoptotic pathway is used o remove self reactive T lymphocytes?

Answer 4

extrinsic

Question 5

Example of physiologic necroptose

Answer 5

growth plate

Question 6

What does P53 does in case of dammage to DNA (2 options)

Answer 6

1. Stops cells in G1 and actiates DNA repair mechanisms
2. Triggers apoptosis if DNA can’t be repaired

Note that a lot of cancers are linked to problems with P53

Question 7

What is the role of t-PAS (theme: coagulation)?

Answer 7

a plasminogen activator (plasminogen->plasmin-> fibrinolysis

Question 8

Résume l’hémostase primaire, et secondaire

Answer 8

primaire: platelet plug
secondaire: facteur tissulaire exposé-> cascade de coagulation-> génération de thrombine-> cleaves fibrinogen in fibrin

Question 9

COagulation: PT et PTT, lequel est la voie extrinseque et lequel intrinseque

Answer 9

PT: extrinseque
PTT: intrinseque

Question 10

hémoarthrose, hémorragies dans muscle: typique plus de hémosase primire ou secondaire?

Answer 10

secondaire?

Question 11

How are called thrombus on heart valves

Question 12

Les thrombus veineux sont dngereux pour quelle raison? et les thrombus dans les artères?

Answer 12

• veine: embolistion dans les poumons
• artère: occlusion d’une artère importante: ex: artere coronaire ou artère cérébrale