David thompson course

Question 1

Name 3 ways by which the endothelium is antithrombotic

Answer 1

1. heparan sulfate binds antithrombin
2. thombomodulin binds thrombin, which is then unable to cleave fibrinogen. Thrombomodulin also activates protein C
3. tissue factor pathway inhibitor inhibits factor X and tissue factor-factor VII , preventing thrombin generation
4. neutral membrane charge on endothelium

Question 2

the tubular system of a platelet is important for storing what (2 things)

Answer 2

Calcium and prostaglandin

Question 3

what does delta platelet granules contain?

Answer 3

calcium

Question 4

Gp11b-111a binds what?

Answer 4

fibrinogen

Question 6

tPA (tissue plasminigen activator) and ______ -> direct activation of fibrinolysis

Answer 6

Urokinase

Question 7

Which is the only fibrillar type of collagen? Also a component of basement membrane (with laminin)

Answer 7

Type IV